3D-printed biomaterials with regional auxetic properties

John J. Warner, Allison R. Gillies, Henry H. Hwang, Hong Zhang, Richard L. Lieber, Shaochen Chen

Research output: Contribution to journalArticle

Abstract

Tissue engineering is replete with methods for inducing and mediating cell differentiation, which are crucial for ensuring proper regrowth of desired tissues. In this study, we developed a 3D-printed, non-positive Poisson's Ratio (NPPR) scaffold intended for future use in stretch-mediated cell differentiation applications, such as in muscle and tendon regeneration. We utilized dynamic optical projection stereolithography (DOPsL) to fabricate multi-layered, cell-laden NPPR scaffolds - these scaffolds can not only support aggregate cell growth, but can also be printed with locally-tunable force-displacement properties at length scales appropriate for tissue interaction. These NPPR multilayered mesh scaffolds can be embedded into highly elastic hydrogels in order to couple a reduced NPPR behavior to a normally Positive Poisson's Ratio (PPR) solid bulk material. This hybrid structure may potentially enable induced 'auxetic' behavior at the single-cell scale while tuning the Poisson's Ratio to a more isolated value. This would be uniquely suited for providing stretch-mediated effects for various cell-types within the tendon-to-muscle tissue transition.

Original languageEnglish (US)
JournalJournal of the Mechanical Behavior of Biomedical Materials
DOIs
StateAccepted/In press - 2017

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Gallbladder Neoplasms
Poisson ratio
Library Catalogs
Scaffolds
Tissue
Commercial Catalogs
Aldehyde Oxidoreductases
Tendons
Muscle
Myoclonic Cerebellar Dyssynergia
Butylene Glycols
Spontaneous Fractures
Traffic Accidents
Myofibrils
Cell growth
Scaffolds (biology)
Tuning
Stereolithography
Tissue engineering
Biomaterials

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

3D-printed biomaterials with regional auxetic properties. / Warner, John J.; Gillies, Allison R.; Hwang, Henry H.; Zhang, Hong; Lieber, Richard L.; Chen, Shaochen.

In: Journal of the Mechanical Behavior of Biomedical Materials, 2017.

Research output: Contribution to journalArticle

Warner, John J.; Gillies, Allison R.; Hwang, Henry H.; Zhang, Hong; Lieber, Richard L.; Chen, Shaochen / 3D-printed biomaterials with regional auxetic properties.

In: Journal of the Mechanical Behavior of Biomedical Materials, 2017.

Research output: Contribution to journalArticle

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