3D-printed biomaterials with regional auxetic properties

John J. Warner, Allison R. Gillies, Henry H. Hwang, Hong Zhang, Richard L. Lieber, Shaochen Chen

Research output: Research - peer-reviewArticle

Abstract

Tissue engineering is replete with methods for inducing and mediating cell differentiation, which are crucial for ensuring proper regrowth of desired tissues. In this study, we developed a 3D-printed, non-positive Poisson's Ratio (NPPR) scaffold intended for future use in stretch-mediated cell differentiation applications, such as in muscle and tendon regeneration. We utilized dynamic optical projection stereolithography (DOPsL) to fabricate multi-layered, cell-laden NPPR scaffolds - these scaffolds can not only support aggregate cell growth, but can also be printed with locally-tunable force-displacement properties at length scales appropriate for tissue interaction. These NPPR multilayered mesh scaffolds can be embedded into highly elastic hydrogels in order to couple a reduced NPPR behavior to a normally Positive Poisson's Ratio (PPR) solid bulk material. This hybrid structure may potentially enable induced 'auxetic' behavior at the single-cell scale while tuning the Poisson's Ratio to a more isolated value. This would be uniquely suited for providing stretch-mediated effects for various cell-types within the tendon-to-muscle tissue transition.

LanguageEnglish (US)
JournalJournal of the Mechanical Behavior of Biomedical Materials
DOIs
StateAccepted/In press - 2017

Fingerprint

Biocompatible Materials
Poisson ratio
Biomaterials
Scaffolds
Tissue
Tendons
Muscle
Stereolithography
Hydrogels
Cell growth
Scaffolds (biology)
Tissue engineering
Tuning

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

3D-printed biomaterials with regional auxetic properties. / Warner, John J.; Gillies, Allison R.; Hwang, Henry H.; Zhang, Hong; Lieber, Richard L.; Chen, Shaochen.

In: Journal of the Mechanical Behavior of Biomedical Materials, 2017.

Research output: Research - peer-reviewArticle

Warner, John J. ; Gillies, Allison R. ; Hwang, Henry H. ; Zhang, Hong ; Lieber, Richard L. ; Chen, Shaochen. / 3D-printed biomaterials with regional auxetic properties. In: Journal of the Mechanical Behavior of Biomedical Materials. 2017
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