3D-printed biomaterials with regional auxetic properties

John J. Warner, Allison R. Gillies, Henry H. Hwang, Hong Zhang, Richard L. Lieber, Shaochen Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Tissue engineering is replete with methods for inducing and mediating cell differentiation, which are crucial for ensuring proper regrowth of desired tissues. In this study, we developed a 3D-printed, non-positive Poisson's Ratio (NPPR) scaffold intended for future use in stretch-mediated cell differentiation applications, such as in muscle and tendon regeneration. We utilized dynamic optical projection stereolithography (DOPsL) to fabricate multi-layered, cell-laden NPPR scaffolds – these scaffolds can not only support aggregate cell growth, but can also be printed with locally-tunable force-displacement properties at length scales appropriate for tissue interaction. These NPPR multilayered mesh scaffolds can be embedded into highly elastic hydrogels in order to couple a reduced NPPR behavior to a normally Positive Poisson's Ratio (PPR) solid bulk material. This hybrid structure may potentially enable induced ‘auxetic’ behavior at the single-cell scale while tuning the Poisson's Ratio to a more isolated value. This would be uniquely suited for providing stretch-mediated effects for various cell-types within the tendon-to-muscle tissue transition.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalJournal of the Mechanical Behavior of Biomedical Materials
StatePublished - Dec 2017

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials


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