3D-printed hyperelastic bone scaffolds accelerate bone regeneration in critical-sized calvarial bone defects

Yu Hui Huang, Adam E. Jakus, Sumanas Wanant Jordan, Zari Dumanian, Kelly Parker, Linping Zhao, Pravin K. Patel, Ramille N. Shah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Autologous bone grafts remain the gold standard for craniofacial reconstruction despite limitations of donor site availability and morbidity. A myriad of commercial bone substitutes and allografts are available, yet no product has gained widespread use due to inferior clinical outcomes. The ideal bone substitute is both osteoconductive and osteoinductive. Craniofacial reconstruction often involves irregular three-dimensional defects, which may benefit from malleable or customizable substrates. "Hyperelastic Bone" (HB) is a 3D-printed synthetic scaffold, composed of 90% by weight hydroxyapatite (HA) and 10% by weight poly(lactic-co-glycolic acid) (PLGA), with inherent bioactivity and porosity to allow for tissue integration. This study examines the capacity of HB for bone regeneration in a critical-sized calvarial defect.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Bone Regeneration
Scaffolds
Bone Substitutes
Bone
Bone and Bones
Defects
Weights and Measures
Porosity
Durapatite
Allografts
Bioactivity
Grafts
Morbidity
Transplants
Availability
Tissue
Hydroxyapatite
Substrates
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Huang, Y. H., Jakus, A. E., Jordan, S. W., Dumanian, Z., Parker, K., Zhao, L., ... Shah, R. N. (2019). 3D-printed hyperelastic bone scaffolds accelerate bone regeneration in critical-sized calvarial bone defects. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Huang, Yu Hui ; Jakus, Adam E. ; Jordan, Sumanas Wanant ; Dumanian, Zari ; Parker, Kelly ; Zhao, Linping ; Patel, Pravin K. ; Shah, Ramille N. / 3D-printed hyperelastic bone scaffolds accelerate bone regeneration in critical-sized calvarial bone defects. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Huang, YH, Jakus, AE, Jordan, SW, Dumanian, Z, Parker, K, Zhao, L, Patel, PK & Shah, RN 2019, 3D-printed hyperelastic bone scaffolds accelerate bone regeneration in critical-sized calvarial bone defects. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

3D-printed hyperelastic bone scaffolds accelerate bone regeneration in critical-sized calvarial bone defects. / Huang, Yu Hui; Jakus, Adam E.; Jordan, Sumanas Wanant; Dumanian, Zari; Parker, Kelly; Zhao, Linping; Patel, Pravin K.; Shah, Ramille N.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Jakus, Adam E.

AU - Jordan, Sumanas Wanant

AU - Dumanian, Zari

AU - Parker, Kelly

AU - Zhao, Linping

AU - Patel, Pravin K.

AU - Shah, Ramille N.

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N2 - Statement of Purpose: Autologous bone grafts remain the gold standard for craniofacial reconstruction despite limitations of donor site availability and morbidity. A myriad of commercial bone substitutes and allografts are available, yet no product has gained widespread use due to inferior clinical outcomes. The ideal bone substitute is both osteoconductive and osteoinductive. Craniofacial reconstruction often involves irregular three-dimensional defects, which may benefit from malleable or customizable substrates. "Hyperelastic Bone" (HB) is a 3D-printed synthetic scaffold, composed of 90% by weight hydroxyapatite (HA) and 10% by weight poly(lactic-co-glycolic acid) (PLGA), with inherent bioactivity and porosity to allow for tissue integration. This study examines the capacity of HB for bone regeneration in a critical-sized calvarial defect.

AB - Statement of Purpose: Autologous bone grafts remain the gold standard for craniofacial reconstruction despite limitations of donor site availability and morbidity. A myriad of commercial bone substitutes and allografts are available, yet no product has gained widespread use due to inferior clinical outcomes. The ideal bone substitute is both osteoconductive and osteoinductive. Craniofacial reconstruction often involves irregular three-dimensional defects, which may benefit from malleable or customizable substrates. "Hyperelastic Bone" (HB) is a 3D-printed synthetic scaffold, composed of 90% by weight hydroxyapatite (HA) and 10% by weight poly(lactic-co-glycolic acid) (PLGA), with inherent bioactivity and porosity to allow for tissue integration. This study examines the capacity of HB for bone regeneration in a critical-sized calvarial defect.

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M3 - Conference contribution

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Huang YH, Jakus AE, Jordan SW, Dumanian Z, Parker K, Zhao L et al. 3D-printed hyperelastic bone scaffolds accelerate bone regeneration in critical-sized calvarial bone defects. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).