3D-Printed Radiopaque Bioresorbable Stents to Improve Device Visualization

Yonghui Ding, Rao Fu, Caralyn Paige Collins, Sarah Fatime Yoda, Cheng Sun*, Guillermo A. Ameer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Bioresorbable stents (BRS) hold great promise for the treatment of many life-threatening luminal diseases. Tracking and monitoring of stents in vivo is critical for avoiding their malposition and inadequate expansion, which often leads to complications and stent failure. However, obtaining high X-ray visibility of polymeric BRS has been challenging because of their intrinsic radiolucency. This study demonstrates the use of photopolymerization-based 3D printing technique to fabricate radiopaque BRS by incorporating iodixanol, a clinical contrast agent, into a bioresorbable citrate-based polymer ink. The successful volumetric dispersion of the iodixanol through the 3D-printing process confers strong X-ray visibility of the produced BRS. Following in vitro degradation, the 3D-printed BRS embedded in chicken muscle maintains high X-ray visibility for at least 4 weeks. Importantly, the 3D-printed radiopaque BRS demonstrates good cytocompatibility and strong mechanical competence in crimping and expansion, which is essential for minimally invasive stent deployment. In addition, it is found that higher loading concentrations of iodixanol, e.g. 10 wt.%, results in more strut fractures in stent crimping and expansion. To conclude, this study introduces a facile strategy to fabricate radiopaque BRS through the incorporation of iodixanol in the 3D printing process, which could potentially increase the clinical success of BRS.

Original languageEnglish (US)
Article number2201955
JournalAdvanced Healthcare Materials
Volume11
Issue number23
DOIs
StatePublished - Dec 7 2022

Keywords

  • X-ray visibility
  • bioresorbable stents
  • iodixanol
  • radiopacity

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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