3[H]-Sulpiride labels mesolimbic non-dopaminergic sites that bind antidepressant drugs

J. G. Csernansky*, C. A. Csernansky, L. E. Hollister

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

3[H]-(-)-Sulpiride and 3[H]-spiperone binding was compared in rat amygdala, nucleus accumbens and striatum, using (+/-)-sulpiride to define specific binding. 3[H]-(-)-Sulpiride bound to twice as many sites in amygdala and nucleus accumbens as 3[H]-spiperone. 3[H]-(-)-Sulpiride binding was directed to these additional sites by using 1 μM spiperone to mask dopaminergic binding. The binding of 3[H]-(-)-sulpiride to these sites was high affinity, reversible, Na+-dependent, but not stereospecific. Metoclopramide, tiapride and antidepressant medications, but not other neuroleptics, ADTN, or serotonin displaced 3[H]-(-)-sulpiride binding to these sites. These data suggest that 3[H]-(-)-sulpiride labels mesolimbic sites other than dopamine receptors which may mediate antidepressant effects.

Original languageEnglish (US)
Pages (from-to)1419-1421
Number of pages3
JournalExperientia
Volume41
Issue number11
DOIs
StatePublished - Nov 1 1985

Keywords

  • Sulpiride
  • alprazolam
  • antidepressants
  • spiperone
  • substituted benzamide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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