3′UTRs take a long shot in the brain

Li Wang, Rui Yi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The fast advancing RNA-seq technology has unveiled an unexpected diversity and expression specificity of 3′ untranslated regions (3′UTRs) of mRNAs. In particular, neural mRNAs seem to express significantly longer 3′UTRs, some of which are over 10kb in length. The extensive elongation of 3′UTRs in neural tissues provides intriguing possibilities for cell type-specific regulations that are governed by miRNAs, RNA-binding proteins and ribonucleoprotein aggregates. In this article, we review recent progress in the characterization of mRNA 3′UTRs and discuss their implications in the understanding of 3′UTR-mediated gene regulation.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalBioEssays
Volume36
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • 3′UTR
  • CeRNAs
  • Polyadenylation
  • RNP aggregates
  • Transcriptome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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