4-Amino-3-alkylbutanoic acids as substrates for γ-aminobutyric acid aminotransferase

R. Andruszkiewicz, R. B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A variety of alkyl-substituted 4-aminobutanoic acid derivatives, including a homologous series of 3-alkyl-4-aminobutanoic acid analogues, 4-methyl isomer analogues, the 3,3-dimethyl analogue, and (E)-4-amino-3-methyl-2-butenoic acid, were synthesized and tested as alternate substrates for purified γ-aminobutyric acid aminotransferase from pig brain. All of the compounds were substrates, but their activities diminished as the size and bulk of the 3-alkyl substituent increased. Several differences were observed between the alkyl-substituted analogues and the corresponding aryl-substituted compounds previously reported (Silverman, R.B., Invergo, B.J., and Levy, M.A. (1987) J. Biol. Chem. 262, 3192-3195). These findings will be important in future designs of inhibitors of γ-aminobutyric acid aminotransferase.

Original languageEnglish (US)
Pages (from-to)22288-22291
Number of pages4
JournalJournal of Biological Chemistry
Volume265
Issue number36
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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