4-(aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase b inactivators

Charles Z. Ding; Richard B. Silverman

doi:10.3109/14756369209020172

4-(aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase b inactivators

Charles Z. Ding^*, Richard B. Silverman

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.

Original language	English (US)
Pages (from-to)	223-231
Number of pages	9
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	6
Issue number	3
DOIs	https://doi.org/10.3109/14756369209020172
State	Published - 1992

Funding

Keywords

4-(aminomethyl)-1-aryl-2-pyrrolidinones
Inactivation
Monoamine oxidase B

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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title = "4-(aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase b inactivators",

abstract = "Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.",

keywords = "4-(aminomethyl)-1-aryl-2-pyrrolidinones, Inactivation, Monoamine oxidase B",

author = "Ding, {Charles Z.} and Silverman, {Richard B.}",

year = "1992",

doi = "10.3109/14756369209020172",

language = "English (US)",

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pages = "223--231",

journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",

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T1 - 4-(aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase b inactivators

AU - Ding, Charles Z.

AU - Silverman, Richard B.

PY - 1992

Y1 - 1992

N2 - Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.

AB - Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.

KW - 4-(aminomethyl)-1-aryl-2-pyrrolidinones

KW - Inactivation

KW - Monoamine oxidase B

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AN - SCOPUS:0027104081

SN - 1475-6366

VL - 6

SP - 223

EP - 231

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

IS - 3

ER -

4-(aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase b inactivators

Abstract

Funding

Keywords

ASJC Scopus subject areas

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