4-(aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase b inactivators

Charles Z. Ding*, Richard B. Silverman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.

Original languageEnglish (US)
Pages (from-to)223-231
Number of pages9
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Issue number3
StatePublished - 1992


  • 4-(aminomethyl)-1-aryl-2-pyrrolidinones
  • Inactivation
  • Monoamine oxidase B

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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