Both 4-(aminomethyl)-l-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1-(methoxyphenyl)-2-pyr-rolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Enzyme Inhibition and Medicinal Chemistry|
|State||Published - Jan 1 1992|
- Monoamine oxidase B
ASJC Scopus subject areas
- Drug Discovery