4-D flow magnetic-resonance-imaging-derived energetic biomarkers are abnormal in children with repaired tetralogy of Fallot and associated with disease severity

Joshua D Robinson*, Michael J. Rose, Maria Joh, Kelly Jarvis, Susanne Schnell, Alex J. Barker, Cynthia K Rigsby, Michael Markl

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights. Objective: To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity. Materials and methods: Pediatric patients post TOF repair (n=21) and controls (n=24) underwent 4-D flow MRI for assessment of time-resolved 3-D blood flow. Data analysis included 3-D segmentation of the right ventricle (RV) and pulmonary artery (PA), with calculation of peak systolic and diastolic kinetic energy (KE) maps. Total KE RV and KE PA were determined from the sum of the KE of all voxels within the respective time-resolved segmentations. Results: KE PA was increased in children post TOF vs. controls across the cardiac cycle, with median 12.5 (interquartile range [IQR] 10.3) mJ/m 2 vs. 8.2 (4.3) mJ/m 2 , P<0.01 in systole; and 2.3 (2.7) mJ/m 2 vs. 1.4 (0.9) mJ/m 2 , P<0.01 in diastole. Diastolic KE PA correlated with systolic KE PA (R 2 0.41, P<0.01) and with pulmonary regurgitation fraction (R 2 0.65, P<0.01). Diastolic KE RV showed similar relationships, denoting increasing KE with higher cardiac outputs and increased right heart volume loading. Diastolic KE RV and KE PA increased with RV end-diastolic volume in a non-linear relationship (R 2 0.33, P<0.01 and R 2 0.50, P<0.01 respectively), with an inflection point near 120 mL/m 2 . Conclusion: Four-dimensional flow-derived KE is abnormal in pediatric patients post TOF repair compared to controls and has a direct, non-linear relationship with traditional measures of disease progression. Future longitudinal studies are needed to evaluate utility for early outcome prediction in TOF.

Original languageEnglish (US)
Pages (from-to)308-317
Number of pages10
JournalPediatric radiology
Volume49
Issue number3
DOIs
StatePublished - Mar 7 2019

Fingerprint

Tetralogy of Fallot
Biomarkers
Magnetic Resonance Imaging
Pulmonary Artery
Heart Ventricles
High Cardiac Output
Pulmonary Valve Insufficiency
Pediatrics
Cardiac Volume
Diastole
Systole
Longitudinal Studies
Disease Progression
Young Adult

Keywords

  • 4-D flow
  • Children
  • Congenital heart disease
  • Heart
  • Kinetic energy
  • Magnetic resonance imaging
  • Pulmonary artery
  • Right ventricle
  • Tetralogy of Fallot

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

@article{979737e8ef544ff49666a32ba211f88c,
title = "4-D flow magnetic-resonance-imaging-derived energetic biomarkers are abnormal in children with repaired tetralogy of Fallot and associated with disease severity",
abstract = "Background: Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights. Objective: To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity. Materials and methods: Pediatric patients post TOF repair (n=21) and controls (n=24) underwent 4-D flow MRI for assessment of time-resolved 3-D blood flow. Data analysis included 3-D segmentation of the right ventricle (RV) and pulmonary artery (PA), with calculation of peak systolic and diastolic kinetic energy (KE) maps. Total KE RV and KE PA were determined from the sum of the KE of all voxels within the respective time-resolved segmentations. Results: KE PA was increased in children post TOF vs. controls across the cardiac cycle, with median 12.5 (interquartile range [IQR] 10.3) mJ/m 2 vs. 8.2 (4.3) mJ/m 2 , P<0.01 in systole; and 2.3 (2.7) mJ/m 2 vs. 1.4 (0.9) mJ/m 2 , P<0.01 in diastole. Diastolic KE PA correlated with systolic KE PA (R 2 0.41, P<0.01) and with pulmonary regurgitation fraction (R 2 0.65, P<0.01). Diastolic KE RV showed similar relationships, denoting increasing KE with higher cardiac outputs and increased right heart volume loading. Diastolic KE RV and KE PA increased with RV end-diastolic volume in a non-linear relationship (R 2 0.33, P<0.01 and R 2 0.50, P<0.01 respectively), with an inflection point near 120 mL/m 2 . Conclusion: Four-dimensional flow-derived KE is abnormal in pediatric patients post TOF repair compared to controls and has a direct, non-linear relationship with traditional measures of disease progression. Future longitudinal studies are needed to evaluate utility for early outcome prediction in TOF.",
keywords = "4-D flow, Children, Congenital heart disease, Heart, Kinetic energy, Magnetic resonance imaging, Pulmonary artery, Right ventricle, Tetralogy of Fallot",
author = "Robinson, {Joshua D} and Rose, {Michael J.} and Maria Joh and Kelly Jarvis and Susanne Schnell and Barker, {Alex J.} and Rigsby, {Cynthia K} and Michael Markl",
year = "2019",
month = "3",
day = "7",
doi = "10.1007/s00247-018-4312-8",
language = "English (US)",
volume = "49",
pages = "308--317",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - 4-D flow magnetic-resonance-imaging-derived energetic biomarkers are abnormal in children with repaired tetralogy of Fallot and associated with disease severity

AU - Robinson, Joshua D

AU - Rose, Michael J.

AU - Joh, Maria

AU - Jarvis, Kelly

AU - Schnell, Susanne

AU - Barker, Alex J.

AU - Rigsby, Cynthia K

AU - Markl, Michael

PY - 2019/3/7

Y1 - 2019/3/7

N2 - Background: Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights. Objective: To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity. Materials and methods: Pediatric patients post TOF repair (n=21) and controls (n=24) underwent 4-D flow MRI for assessment of time-resolved 3-D blood flow. Data analysis included 3-D segmentation of the right ventricle (RV) and pulmonary artery (PA), with calculation of peak systolic and diastolic kinetic energy (KE) maps. Total KE RV and KE PA were determined from the sum of the KE of all voxels within the respective time-resolved segmentations. Results: KE PA was increased in children post TOF vs. controls across the cardiac cycle, with median 12.5 (interquartile range [IQR] 10.3) mJ/m 2 vs. 8.2 (4.3) mJ/m 2 , P<0.01 in systole; and 2.3 (2.7) mJ/m 2 vs. 1.4 (0.9) mJ/m 2 , P<0.01 in diastole. Diastolic KE PA correlated with systolic KE PA (R 2 0.41, P<0.01) and with pulmonary regurgitation fraction (R 2 0.65, P<0.01). Diastolic KE RV showed similar relationships, denoting increasing KE with higher cardiac outputs and increased right heart volume loading. Diastolic KE RV and KE PA increased with RV end-diastolic volume in a non-linear relationship (R 2 0.33, P<0.01 and R 2 0.50, P<0.01 respectively), with an inflection point near 120 mL/m 2 . Conclusion: Four-dimensional flow-derived KE is abnormal in pediatric patients post TOF repair compared to controls and has a direct, non-linear relationship with traditional measures of disease progression. Future longitudinal studies are needed to evaluate utility for early outcome prediction in TOF.

AB - Background: Cardiac MRI plays a central role in monitoring children with repaired tetralogy of Fallot (TOF) for long-term complications. Current risk assessment is based on volumetric and functional parameters that measure late expression of underlying physiological changes. Emerging 4-D flow MRI techniques promise new insights. Objective: To assess whether 4-D flow MRI-derived measures of blood kinetic energy (1) differentiate children and young adults with TOF from controls and (2) are associated with disease severity. Materials and methods: Pediatric patients post TOF repair (n=21) and controls (n=24) underwent 4-D flow MRI for assessment of time-resolved 3-D blood flow. Data analysis included 3-D segmentation of the right ventricle (RV) and pulmonary artery (PA), with calculation of peak systolic and diastolic kinetic energy (KE) maps. Total KE RV and KE PA were determined from the sum of the KE of all voxels within the respective time-resolved segmentations. Results: KE PA was increased in children post TOF vs. controls across the cardiac cycle, with median 12.5 (interquartile range [IQR] 10.3) mJ/m 2 vs. 8.2 (4.3) mJ/m 2 , P<0.01 in systole; and 2.3 (2.7) mJ/m 2 vs. 1.4 (0.9) mJ/m 2 , P<0.01 in diastole. Diastolic KE PA correlated with systolic KE PA (R 2 0.41, P<0.01) and with pulmonary regurgitation fraction (R 2 0.65, P<0.01). Diastolic KE RV showed similar relationships, denoting increasing KE with higher cardiac outputs and increased right heart volume loading. Diastolic KE RV and KE PA increased with RV end-diastolic volume in a non-linear relationship (R 2 0.33, P<0.01 and R 2 0.50, P<0.01 respectively), with an inflection point near 120 mL/m 2 . Conclusion: Four-dimensional flow-derived KE is abnormal in pediatric patients post TOF repair compared to controls and has a direct, non-linear relationship with traditional measures of disease progression. Future longitudinal studies are needed to evaluate utility for early outcome prediction in TOF.

KW - 4-D flow

KW - Children

KW - Congenital heart disease

KW - Heart

KW - Kinetic energy

KW - Magnetic resonance imaging

KW - Pulmonary artery

KW - Right ventricle

KW - Tetralogy of Fallot

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U2 - 10.1007/s00247-018-4312-8

DO - 10.1007/s00247-018-4312-8

M3 - Article

VL - 49

SP - 308

EP - 317

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

IS - 3

ER -