4D embryonic cardiography using gated optical coherence tomography

M. W. Jenkins; F. Rothenberg; D. Roy; V. P. Nikolski; Z. Hu; M. Watanabe; D. L. Wilson; I. R. Efimov; A. M. Rollins

doi:10.1364/OPEX.14.000736

4D embryonic cardiography using gated optical coherence tomography

M. W. Jenkins^*, F. Rothenberg, D. Roy, V. P. Nikolski, Z. Hu, M. Watanabe, D. L. Wilson, I. R. Efimov, A. M. Rollins

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 μm), and with a depth penetration of 1.5 - 2.0 mm that is suitable for the study of early embryonic hearts. We acquired data from paced, excised, embryonic chicken and mouse hearts using gated sampling and employed image processing techniques to visualize the hearts in 4D and measure physiologic parameters such as cardiac volume, ejection fraction, and wall thickness. This technique is being developed to longitudinally investigate the physiology of intact embryonic hearts and events that lead to congenital heart defects.

Original language	English (US)
Pages (from-to)	736-748
Number of pages	13
Journal	Optics Express
Volume	14
Issue number	2
DOIs	https://doi.org/10.1364/OPEX.14.000736
State	Published - Jan 23 2006

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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abstract = "Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 μm), and with a depth penetration of 1.5 - 2.0 mm that is suitable for the study of early embryonic hearts. We acquired data from paced, excised, embryonic chicken and mouse hearts using gated sampling and employed image processing techniques to visualize the hearts in 4D and measure physiologic parameters such as cardiac volume, ejection fraction, and wall thickness. This technique is being developed to longitudinally investigate the physiology of intact embryonic hearts and events that lead to congenital heart defects.",

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AU - Jenkins, M. W.

AU - Rothenberg, F.

AU - Roy, D.

AU - Nikolski, V. P.

AU - Hu, Z.

AU - Watanabe, M.

AU - Wilson, D. L.

AU - Efimov, I. R.

AU - Rollins, A. M.

PY - 2006/1/23

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AB - Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 μm), and with a depth penetration of 1.5 - 2.0 mm that is suitable for the study of early embryonic hearts. We acquired data from paced, excised, embryonic chicken and mouse hearts using gated sampling and employed image processing techniques to visualize the hearts in 4D and measure physiologic parameters such as cardiac volume, ejection fraction, and wall thickness. This technique is being developed to longitudinally investigate the physiology of intact embryonic hearts and events that lead to congenital heart defects.

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4D embryonic cardiography using gated optical coherence tomography

Abstract

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