Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Medicinal Chemistry|
|State||Published - Mar 1 1992|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery