5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine Oxidase-B Inactivators

Zhaozhong Ding; Richard B. Silverman

doi:10.1021/jm00083a012

5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine Oxidase-B Inactivators

Zhaozhong Ding, Richard B. Silverman^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.

Original language	English (US)
Pages (from-to)	885-889
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	35
Issue number	5
DOIs	https://doi.org/10.1021/jm00083a012
State	Published - Mar 1 1992

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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abstract = "Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.",

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5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine Oxidase-B Inactivators

Abstract

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