5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine Oxidase-B Inactivators

Zhaozhong Ding, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.

Original languageEnglish (US)
Pages (from-to)885-889
Number of pages5
JournalJournal of Medicinal Chemistry
Volume35
Issue number5
DOIs
StatePublished - Mar 1 1992

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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