5-HIAA in cerebrospinal fluid and deficit schizophrenic characteristics

J. G. Csernansky*, R. J. King, W. O. Faustman, J. A. Moses, M. E. Poscher, K. F. Faull

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Higher CSF 5-HIAA concentrations and lower CSF HVA concentrations have been associated with various measures of slowed motor behaviour and communication in schizophrenic patients. To derive a single, reliable measure of deficit characteristics in schizophrenic patients, we entered four items of the BPRS reflecting negative symptoms, a work history measure derived from the Strauss-Carpenter scale, and three subscale scores of the WAIS-R into a principal-components analysis to derive a single factor score. The CSF 5-HIAA concentrations were within the normal range of values, and correlated directly with this factor score, but CSF HVA concentrations were not associated with the deficit factor score. These findings add support to the hypothesis that brain serotonin function is associated with deficit schizophrenic characteristics.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalBritish Journal of Psychiatry
Volume156
Issue numberAPR.
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Csernansky, J. G., King, R. J., Faustman, W. O., Moses, J. A., Poscher, M. E., & Faull, K. F. (1990). 5-HIAA in cerebrospinal fluid and deficit schizophrenic characteristics. British Journal of Psychiatry, 156(APR.), 501-507. https://doi.org/10.1192/bjp.156.4.501