5-HT2A receptor stimulation by DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

Toshihide Kuroki*, Herbert Y. Meltzer, Junji Ichikawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

(±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalBrain research
Volume972
Issue number1-2
DOIs
StatePublished - May 16 2003

Keywords

  • 5-HT receptor
  • Amphetamine
  • Dopamine
  • M100907
  • Microdialysis
  • Rat
  • [1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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