5-Hydroxytryptophan-induced cortisol response and CSF 5-HIAA in depressed patients

T. Koyama, M. T. Lowy, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients. They found a significant negative correlation with CSF levels of 5-hydroxyindoleacetic acid, a 5-HT metabolite, but not with CSF levels of other monoamine metabolites. This finding is consistent with the hypothesis that low presynaptic brain serotonergic activity may be related to enhanced cortisol response to 5-HTP in depressed patients.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalAmerican Journal of Psychiatry
Volume144
Issue number3
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Psychiatry and Mental health

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