5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions

Rene Hennig, Paul Grippo, Xian Zhong Ding, Sambasiva M. Rao, Markus W. Buchler, Helmut Friess, Mark S. Talamonti, Richard H. Bell, Thomas E. Adrian*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Pancreatic cancer has an abysmal prognosis because of late diagnosis. Therefore, it is important to identify risk factors if we are to be able to prevent and detect this cancer in an early, noninvasive stage. Pancreatic intraepithelial neoplasias (PanIN) are the precursor lesions which could be an ideal target for chemoprevention. This study shows up-regulation of 5-lipoxygenase (5-LOX) in all grades of human PanINs and early lesions of pancreatic cancer in two different animal models (EL-Kras mice and N-nitrosobis(2-oxopropyl)amine-treated hamsters) by immunohistochemistry. The results were consistent in all tissues examined, including seven chronic pancreatitis patients, four pancreatic cancer patients, one multiorgan donor, nine EL-Kras mice, and three N-nitrosobis(2-oxopropyl)amine-treated hamsters, all with PanINs. Overexpression of 5-LOX in NIH3T3 cells resulted in greater sensitivity of these cells to the growth inhibitory effects of the 5-LOX inhibitor Rev5901. These findings provide evidence that 5-LOX plays a key role in the development of pancreatic cancer. Furthermore, the lipoxygenase pathway may be a target for the prevention of this devastating disease.

Original languageEnglish (US)
Pages (from-to)6011-6016
Number of pages6
JournalCancer Research
Volume65
Issue number14
DOIs
StatePublished - Jul 15 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of '5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions'. Together they form a unique fingerprint.

  • Cite this

    Hennig, R., Grippo, P., Ding, X. Z., Rao, S. M., Buchler, M. W., Friess, H., Talamonti, M. S., Bell, R. H., & Adrian, T. E. (2005). 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Cancer Research, 65(14), 6011-6016. https://doi.org/10.1158/0008-5472.CAN-04-4090