5‐drug adjuvant chemotherapy for breast cancer

Robert W. Carey*, W. Davies Sohier, Sheldon Kaufman, Sigmund A. Weitzman, Rita M. Kelley, Robert A. Lew, Elkan Halpern

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of 41 patients at the MGH who received 5‐drug chemotherapy, cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine and prednisone, (CMF VP) as adjuvant to surgical treatment of operable breast cancer with 4 or more positive axillary nodes is compared to an analogous group of patients treated with cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) reported by Bonadonna et al.1 in an effort to assess the contribution of the treatment program to disease control. The MGH pattern of disease free survival closely parallels that of Bonadonna.2 Median disease‐free survival among the 24 patients who have not recurred is 27 months; among those who recurred 18 months. The analogous medians for treated patients in the Bonadonna study are 24 months and 16 months, as compared to 27 months and 8 months for his nontreated controls. The treatment program, carried out over a two year period, was well tolerated with excellent patient compliance. There was no significant impact, however, in the disease‐free survival of postmenopausal patients. While use of this regimen improved disease‐free survival in premenopausal individuals, it is clear that a great deal of room for improvement exists, and newer regimens should be investigated.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalCancer
Volume44
Issue number1
DOIs
StatePublished - Jan 1 1979

Fingerprint

Adjuvant Chemotherapy
Breast Neoplasms
Methotrexate
Cyclophosphamide
Survival
Vincristine
Patient Compliance
Prednisone
Disease-Free Survival
Therapeutics
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Carey, R. W., Davies Sohier, W., Kaufman, S., Weitzman, S. A., Kelley, R. M., Lew, R. A., & Halpern, E. (1979). 5‐drug adjuvant chemotherapy for breast cancer. Cancer, 44(1), 35-41. https://doi.org/10.1002/1097-0142(197907)44:1<35::AID-CNCR2820440107>3.0.CO;2-S
Carey, Robert W. ; Davies Sohier, W. ; Kaufman, Sheldon ; Weitzman, Sigmund A. ; Kelley, Rita M. ; Lew, Robert A. ; Halpern, Elkan. / 5‐drug adjuvant chemotherapy for breast cancer. In: Cancer. 1979 ; Vol. 44, No. 1. pp. 35-41.
@article{b87c4421965341558a888ade7da6b3a9,
title = "5‐drug adjuvant chemotherapy for breast cancer",
abstract = "A series of 41 patients at the MGH who received 5‐drug chemotherapy, cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine and prednisone, (CMF VP) as adjuvant to surgical treatment of operable breast cancer with 4 or more positive axillary nodes is compared to an analogous group of patients treated with cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) reported by Bonadonna et al.1 in an effort to assess the contribution of the treatment program to disease control. The MGH pattern of disease free survival closely parallels that of Bonadonna.2 Median disease‐free survival among the 24 patients who have not recurred is 27 months; among those who recurred 18 months. The analogous medians for treated patients in the Bonadonna study are 24 months and 16 months, as compared to 27 months and 8 months for his nontreated controls. The treatment program, carried out over a two year period, was well tolerated with excellent patient compliance. There was no significant impact, however, in the disease‐free survival of postmenopausal patients. While use of this regimen improved disease‐free survival in premenopausal individuals, it is clear that a great deal of room for improvement exists, and newer regimens should be investigated.",
author = "Carey, {Robert W.} and {Davies Sohier}, W. and Sheldon Kaufman and Weitzman, {Sigmund A.} and Kelley, {Rita M.} and Lew, {Robert A.} and Elkan Halpern",
year = "1979",
month = "1",
day = "1",
doi = "10.1002/1097-0142(197907)44:1<35::AID-CNCR2820440107>3.0.CO;2-S",
language = "English (US)",
volume = "44",
pages = "35--41",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

Carey, RW, Davies Sohier, W, Kaufman, S, Weitzman, SA, Kelley, RM, Lew, RA & Halpern, E 1979, '5‐drug adjuvant chemotherapy for breast cancer', Cancer, vol. 44, no. 1, pp. 35-41. https://doi.org/10.1002/1097-0142(197907)44:1<35::AID-CNCR2820440107>3.0.CO;2-S

5‐drug adjuvant chemotherapy for breast cancer. / Carey, Robert W.; Davies Sohier, W.; Kaufman, Sheldon; Weitzman, Sigmund A.; Kelley, Rita M.; Lew, Robert A.; Halpern, Elkan.

In: Cancer, Vol. 44, No. 1, 01.01.1979, p. 35-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 5‐drug adjuvant chemotherapy for breast cancer

AU - Carey, Robert W.

AU - Davies Sohier, W.

AU - Kaufman, Sheldon

AU - Weitzman, Sigmund A.

AU - Kelley, Rita M.

AU - Lew, Robert A.

AU - Halpern, Elkan

PY - 1979/1/1

Y1 - 1979/1/1

N2 - A series of 41 patients at the MGH who received 5‐drug chemotherapy, cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine and prednisone, (CMF VP) as adjuvant to surgical treatment of operable breast cancer with 4 or more positive axillary nodes is compared to an analogous group of patients treated with cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) reported by Bonadonna et al.1 in an effort to assess the contribution of the treatment program to disease control. The MGH pattern of disease free survival closely parallels that of Bonadonna.2 Median disease‐free survival among the 24 patients who have not recurred is 27 months; among those who recurred 18 months. The analogous medians for treated patients in the Bonadonna study are 24 months and 16 months, as compared to 27 months and 8 months for his nontreated controls. The treatment program, carried out over a two year period, was well tolerated with excellent patient compliance. There was no significant impact, however, in the disease‐free survival of postmenopausal patients. While use of this regimen improved disease‐free survival in premenopausal individuals, it is clear that a great deal of room for improvement exists, and newer regimens should be investigated.

AB - A series of 41 patients at the MGH who received 5‐drug chemotherapy, cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine and prednisone, (CMF VP) as adjuvant to surgical treatment of operable breast cancer with 4 or more positive axillary nodes is compared to an analogous group of patients treated with cyclophosphamide, methotrexate and 5‐fluorouracil (CMF) reported by Bonadonna et al.1 in an effort to assess the contribution of the treatment program to disease control. The MGH pattern of disease free survival closely parallels that of Bonadonna.2 Median disease‐free survival among the 24 patients who have not recurred is 27 months; among those who recurred 18 months. The analogous medians for treated patients in the Bonadonna study are 24 months and 16 months, as compared to 27 months and 8 months for his nontreated controls. The treatment program, carried out over a two year period, was well tolerated with excellent patient compliance. There was no significant impact, however, in the disease‐free survival of postmenopausal patients. While use of this regimen improved disease‐free survival in premenopausal individuals, it is clear that a great deal of room for improvement exists, and newer regimens should be investigated.

UR - http://www.scopus.com/inward/record.url?scp=0018760807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018760807&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(197907)44:1<35::AID-CNCR2820440107>3.0.CO;2-S

DO - 10.1002/1097-0142(197907)44:1<35::AID-CNCR2820440107>3.0.CO;2-S

M3 - Article

C2 - 455262

AN - SCOPUS:0018760807

VL - 44

SP - 35

EP - 41

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 1

ER -