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• Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis

  Weerawarna, P. M., Schiefer, I. T., Soares, P., Fox, S., Morimoto, R. I., Melani, R. D., Kelleher, N. L., Luan, C. H. & Silverman, R. B., Jan 24 2024, In: ACS Central Science. 10, 1, p. 87-103 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• NU-9 improves health of hSOD1^G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone

  Genç, B., Gautam, M., Helmold, B. R., Koçak, N., Günay, A., Goshu, G. M., Silverman, R. B. & Hande Ozdinler, P., Dec 2022, In: Scientific reports. 12, 1, 5383.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Scopus citations

• Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

  Genç, B., Gautam, M., Gözütok, Ö., Dervishi, I., Sanchez, S., Goshu, G. M., Koçak, N., Xie, E., Silverman, R. B. & Özdinler, P. H., Feb 1 2021, In: Clinical and Translational Medicine. 11, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The impact of the approval of riluzole

  Sufit, R. & Newman, D., 1996, In: Neurology. 47, 4 SUPPL., p. S117

  Research output: Contribution to journal › Short survey › peer-review
  1 Scopus citations

• A Cost-Effectiveness Framework for Amyotrophic Lateral Sclerosis, Applied to Riluzole

  Thakore, N. J., Pioro, E. P., Udeh, B. L., Lapin, B. R. & Katzan, I. L., Dec 2020, In: Value in Health. 23, 12, p. 1543-1551 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Scopus citations

• Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels

  Song, J. H., Huang, C. S., Nagata, K., Yeh, J. Z. & Narahashi, T., Aug 1997, In: Journal of Pharmacology and Experimental Therapeutics. 282, 2, p. 707-714 8 p.

  Research output: Contribution to journal › Article › peer-review
  162 Scopus citations

• Clinical trials of riluzole in patients with ALS

  Miller, R. G., Bouchard, J. P., Duquette, P., Eisen, A., Gelinas, D., Harati, Y., Munsat, T. L., Powe, L., Rothstein, J., Salzman, P. & Sufit, R. L., Oct 1996, In: Neurology. 47, 4 SUPPL., p. S86-S92

  Research output: Contribution to journal › Article › peer-review
  64 Scopus citations

• Stage-specific riluzole effect in amyotrophic lateral sclerosis: a retrospective study

  Pooled Resource Open-Access Als Clinical Trials Consortium, Jan 2 2020, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 21, 1-2, p. 140-143 4 p.

  Research output: Contribution to journal › Article › peer-review
  16 Scopus citations

• Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis

  Andrews, J. A., Jackson, C. E., Heiman-Patterson, T. D., Bettica, P., Brooks, B. R. & Pioro, E. P., 2020, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 21, 7-8, p. 509-518 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  91 Scopus citations

• Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS

  Ajroud-Driss, S., Saeed, M., Khan, H., Siddique, N., Hung, W. Y., Sufit, R., Heller, S., Armstrong, J., Casey, P., Siddique, T. & Lukas, T. J., 2007, In: Amyotrophic Lateral Sclerosis. 8, 5, p. 305-309 5 p.

  Research output: Contribution to journal › Article › peer-review
  13 Scopus citations

• Effect of prolonged riluzole exposure on cultured motoneurons in a mouse model of ALS

  Schuster, J. E., Fu, R., Siddique, T. & Heckman, C. J., Jan 2012, In: Journal of neurophysiology. 107, 1, p. 484-492 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Scopus citations

• Effects of the neuroprotective agent riluzole on the high voltage- activated calcium channels of rat dorsal root ganglion neurons

  Huang, C. S., Song, J. H., Nagata, K., Yeh, J. Z. & Narahashi, T., Sep 1997, In: Journal of Pharmacology and Experimental Therapeutics. 282, 3, p. 1280-1290 11 p.

  Research output: Contribution to journal › Article › peer-review
  118 Scopus citations

• Riluzole decreases flexion withdrawal reflex but not voluntary ankle torque in human chronic spinal cord injury

  Theiss, R. D., Hornby, T. G., Rymer, W. Z. & Schmit, B. D., Jun 2011, In: Journal of neurophysiology. 105, 6, p. 2781-2790 10 p.

  Research output: Contribution to journal › Article › peer-review
  21 Scopus citations

• Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis

  Elmansy, M. F., Reidl, C. T., Rahaman, M., Özdinler, P. H. & Silverman, R. B., Nov 2023, In: Medicinal Research Reviews. 43, 6, p. 2260-2302 43 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  4 Scopus citations

• Treatment of amyotrophic lateral sclerosis

  Kirsch, D. R. (Inventor), Benmohamed, R. (Inventor), Arvanites, A. C. (Inventor), Morimoto, R. I. (Inventor), Chen, T. (Inventor) & Silverman, R. (Inventor), Jan 1 2019, Patent No. 10167263

  Research output: Patent

  Open Access

  File
  2 Downloads (Pure)

• Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis

  Xia, G., Benmohamed, R., Kim, J., Arvanites, A. C., Morimoto, R. I., Ferrante, R. J., Kirsch, D. R. & Silverman, R. B., Apr 14 2011, In: Journal of Medicinal Chemistry. 54, 7, p. 2409-2421 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  43 Scopus citations

• CYCLOHEXANE-1,3-DIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

  Kirsch, D. R. (Inventor), Benmohamed, R. (Inventor), Arvanites, A. C. (Inventor), Morimoto, R. I. (Inventor), Zhang, W. (Inventor) & Silverman, R. (Inventor), May 13 2014, Patent No. 8722939

  Research output: Patent

  File
  3 Downloads (Pure)

• Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS

  Zhang, Y., Benmohamed, R., Zhang, W., Kim, J., Edgerly, C. K., Zhu, Y., Morimoto, R. I., Ferrante, R. J., Kirsch, D. R. & Silverman, R. B., Jul 12 2012, In: ACS Medicinal Chemistry Letters. 3, 7, p. 584-587 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  18 Scopus citations

• Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models: Laboratory investigation

  Yohay, K., Tyler, B., Weaver, K. D., Pardo, A. C., Gincel, D., Blakeley, J., Brem, H. & Rothstein, J. D., Apr 2014, In: Journal of neurosurgery. 120, 4, p. 854-863 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Scopus citations

• G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons

  Huang, C. S., Song, J. H., Nagata, K., Twombly, D., Yeh, J. Z. & Narahashi, T., Jul 11 1997, In: Brain research. 762, 1-2, p. 235-239 5 p.

  Research output: Contribution to journal › Article › peer-review
  15 Scopus citations

• Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells

  Zhang, W., Benmohamed, R., Arvanites, A. C., Morimoto, R. I., Ferrante, R. J., Kirsch, D. R. & Silverman, R. B., Jan 15 2012, In: Bioorganic and Medicinal Chemistry. 20, 2, p. 1029-1045 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Scopus citations

• The Organic Chemistry of Drug Design and Drug Action

  Silverman, R. B., 1992, San Diego: Academic Press.

  Research output: Book/Report › Book

• Medizinische Chemie für Organiker, Biochemiker und Pharmazeutische Chemiker

  Silverman, R. B., 1995, Weinheim: VCH.

  Research output: Book/Report › Book

• Miscellaneous Selenium-Containing Heterocycles

  Silverman, R. B., 1973, Organic Selenium Compounds: Their Chemistry and Biology. New York: Wiley-Interscience

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Mechanism-Based Enzyme Inactivators

  Silverman, R. B., 1996, Contemporary Enzyme Kinetics and Mechanism. Purich, D. L. (ed.). 2nd ed. San Diego: Academic Press, p. 291-334

  Research output: Chapter in Book/Report/Conference proceeding › Chapter