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  • Richard J Miller
2020

Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis

Miller, R. E., Tran, P. B., Ishihara, S., Syx, D., Ren, D., Miller, R. J., Valdes, A. M. & Malfait, A. M., May 2020, In : Osteoarthritis and Cartilage. 28, 5, p. 581-592 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The innate immune response as a mediator of osteoarthritis pain

Miller, R. J., Malfait, A. M. & Miller, R. E., May 2020, In : Osteoarthritis and Cartilage. 28, 5, p. 562-571 10 p.

Research output: Contribution to journalReview article

3 Scopus citations
2019

The nociceptive innervation of the normal and osteoarthritic mouse knee

Obeidat, A. M., Miller, R. E., Miller, R. J. & Malfait, A. M., Jan 1 2019, (Accepted/In press) In : Osteoarthritis and Cartilage.

Research output: Contribution to journalArticle

3 Scopus citations
2018

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Miller, R. E., Ishihara, S., Tran, P. B., Golub, S. B., Last, K., Miller, R. J., Fosang, A. J. & Malfait, A. M., Mar 22 2018, In : JCI Insight. 3, 6

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

Jayaraj, N. D., Bhattacharyya, B. J., Belmadani, A. A., Ren, D., Rathwell, C. A., Hackelberg, S., Hopkins, B. E., Gupta, H. R., Miller, R. J. & Menichella, D. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2205-2225 21 p.

Research output: Contribution to journalArticle

14 Scopus citations

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain

Rosen, J. M., Yaggie, R. E., Woida, P. J., Miller, R. J., Schaeffer, A. J. & Klumpp, D., Dec 1 2018, In : Scientific Reports. 8, 1, 7188.

Research output: Contribution to journalArticle

4 Scopus citations

Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging

Miller, R. E., Kim, Y. S., Tran, P. B., Ishihara, S., Dong, X., Miller, R. J. & Malfait, A. M., Jan 2018, In : Arthritis and Rheumatology. 70, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

Miller, R. E., Ishihara, S., Bhattacharyya, B., Delaney, A., Menichella, D. M., Miller, R. J. & Malfait, A. M., Jul 2017, In : Arthritis and Rheumatology. 69, 7, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evidence for an early innate immune response in the motor cortex of ALS

Jara, J. H., Genç, B., Stanford, M. J., Pytel, P., Roos, R. P., Weintraub, S., Mesulam, M. M., Bigio, E. H., Miller, R. J. & Özdinler, P. H., Jun 26 2017, In : Journal of neuroinflammation. 14, 1, 129.

Research output: Contribution to journalArticle

7 Scopus citations

Is cannabis an effective treatment for joint pain?

Miller, R. J. & Miller, R. E., Jan 1 2017, In : Clinical and Experimental Rheumatology. 35, 5, p. S59-S67

Research output: Contribution to journalArticle

8 Scopus citations

Spinal microglial activation in a murine surgical model of knee osteoarthritis

Tran, P. B., Miller, R. E., Ishihara, S., Miller, R. J. & Malfait, A. M., May 2017, In : Osteoarthritis and Cartilage. 25, 5, p. 718-726 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016
23 Scopus citations

Distribution and pharmacology of the enkephalins

Miller, R. J., Meltzer, H. Y. & Fang, V. S., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 3-16 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Emerging Targets for the Management of Osteoarthritis Pain

Malfait, A. M. & Miller, R. J., Dec 1 2016, In : Current Osteoporosis Reports. 14, 6, p. 260-268 9 p.

Research output: Contribution to journalReview article

19 Scopus citations

Ganglioside GM3 synthase depletion reverses neuropathic pain and small fiber neuropathy in diet-induced diabetic mice

Menichella, D. M., Jayaraj, N. D., Wilson, H. M., Ren, D., Flood, K., Wang, X. Q., Shum, A., Miller, R. J. & Paller, A. S., Aug 1 2016, In : Molecular Pain. 12

Research output: Contribution to journalArticle

6 Scopus citations

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

Varvel, N. H., Neher, J. J., Bosch, A., Wang, W., Ransohoff, R. M., Miller, R. J. & Dingledine, R., Sep 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. E5665-E5674

Research output: Contribution to journalArticle

101 Scopus citations

Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions

Banisadr, G., Podojil, J. R., Miller, S. D. & Miller, R. J., Mar 1 2016, In : Journal of Neuroimmune Pharmacology. 11, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Role of adult hippocampal neurogenesis in persistent pain

Apkarian, A. V., Mutso, A. A., Centeno, M. V., Kan, L., Wu, M., Levinstein, M., Banisadr, G., Gobeske, K. T., Miller, R. J., Radulovic, J., Hen, R. & Kessler, J. A., Feb 1 2016, In : Pain. 157, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2015

A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart

Cheng, M., Huang, K., Zhou, J., Yan, D., Tang, Y. L., Zhao, T. C., Miller, R. J., Kishore, R., Losordo, D. W. & Qin, G., Apr 1 2015, In : Journal of Molecular and Cellular Cardiology. 81, p. 49-53 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through toll-like receptor 4

Miller, R. E., Belmadani, A., Ishihara, S., Tran, P. B., Ren, D., Miller, R. J. & Malfait, A. M., Nov 1 2015, In : Arthritis and Rheumatology. 67, 11, p. 2933-2943 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Identification of a sustained neurogenic zone at the dorsal surface of the adult mouse hippocampus and its regulation by the chemokine SDF-1

Belmadani, A., Ren, D., Bhattacharyya, B. J., Rothwangl, K. B., Hope, T. J., Perlman, H. & Miller, R. J., Nov 2015, In : Hippocampus. 25, 11, p. 1224-1241 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Localized CCR2 activation in the bone marrow niche mobilizes monocytes by desensitizing CXCR4

Jung, H., Mithal, D. S., Park, J. E. & Miller, R. J., Jun 1 2015, In : PloS one. 10, 6, e0128387.

Research output: Contribution to journalArticle

22 Scopus citations

Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS

Watson, J. A., Bhattacharyya, B. J., Vaden, J. H., Wilson, J. A., Icyuz, M., Howard, A. D., Phillips, E., DeSilva, T. M., Siegal, G. P., Bean, A. J., King, G. D., Phillips, S. E., Miller, R. J. & Wilson, S. M., Jul 1 2015, In : PLoS genetics. 11, 6, e1005290.

Research output: Contribution to journalArticle

10 Scopus citations

Neutrophil trails guide influenzaspecific CD8+ T cells in the airways

Lim, K., Hyun, Y. M., Lambert-Emo, K., Capece, T., Bae, S., Miller, R. J., Topham, D. J. & Kim, M., Sep 4 2015, In : Science. 349, 6252, 1071.

Research output: Contribution to journalArticle

165 Scopus citations

Stimulation of hERG1 channel activity promotes a calciumdependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells

Perez-Neut, M., Shum, A., Cuevas, B. D., Miller, R. & Gentile, S., Jan 1 2015, In : Oncotarget. 6, 3, p. 1631-1639 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

Miller, R. E., Tran, P. B., Obeidat, A. M., Raghu, P., Ishihara, S., Miller, R. J. & Malfait, A. M., Oct 7 2015, In : Current Osteoporosis Reports. 13, 5, p. 318-326 9 p.

Research output: Contribution to journalReview article

13 Scopus citations

Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction

Vaden, J. H., Bhattacharyya, B. J., Chen, P. C., Watson, J. A., Marshall, A. G., Phillips, S. E., Wilson, J. A., King, G. D., Miller, R. J. & Wilson, S. M., Jan 10 2015, In : Molecular neurodegeneration. 10, 1, 3.

Research output: Contribution to journalArticle

25 Scopus citations

Visualization of sensory neurons and their projections in an upper motor neuron reporter line

Genç, B., Lagrimas, A. K. B., Kuru, P., Hess, R., Tu, M. W., Menichella, D. M., Miller, R. J., Paller, A. S. & Özdinler, P. H., Jul 29 2015, In : PloS one. 10, 7, e0132815.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications

Van Leeuwen, J. E., Rafalovich, I., Sellers, K., Jones, K. A., Griffith, T. N., Huda, R., Miller, R. J., Srivastava, D. P. & Penzes, P., Apr 11 2014, In : Journal of Biological Chemistry. 289, 15, p. 10831-10842 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy

Menichella, D. M., Abdelhak, B., Ren, D., Shum, A., Frietag, C. & Miller, R. J., Jun 25 2014, In : Molecular Pain. 10, 1, 42.

Research output: Contribution to journalArticle

29 Scopus citations

Distribution of MT1 Melatonin Receptor Promoter-Driven RFP Expression in the Brains of BAC C3H/HeN Transgenic Mice

Adamah-Biassi, E. B., Zhang, Y., Jung, H., Vissapragada, S., Miller, R. J. & Dubocovich, M. L., Jan 1 2014, In : Journal of Histochemistry and Cytochemistry. 62, 1, p. 70-84 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth

Haldipur, P., Gillies, G. S., Janson, O. K., Chizhikov, V. V., Mithal, D. S., Miller, R. J. & Millen, K. J., 2014, In : eLife. 3, e03962.

Research output: Contribution to journalArticle

25 Scopus citations

How does ubiquitin regulate synapses? Let me count the ways

Miller, R. J., Feb 15 2014, In : Journal of Physiology. 592, 4, p. 555-556 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Integrin/chemokine receptor interactions in the pathogenesis of experimental autoimmune encephalomyelitis

Banisadr, G., Schwartz, S. R., Podojil, J. R., Piccinini, L. A., Lanker, S., Miller, S. D. & Miller, R. J., Jun 2014, In : Journal of Neuroimmune Pharmacology. 9, 3, p. 438-445 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Lipid Modulation of Calcium Flux through CaV2.3 Regulates Acrosome Exocytosis and Fertilization

Cohen, R., Buttke, D. E., Asano, A., Mukai, C., Nelson, J. L., Ren, D., Miller, R. J., Cohen-Kutner, M., Atlas, D. & Travis, A. J., Feb 10 2014, In : Developmental Cell. 28, 3, p. 310-321 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies

Malchenko, S., Xie, J., de Fatima Bonaldo, M., Vanin, E. F., Bhattacharyya, B. J., Belmadani, A., Xi, G., Galat, V., Goossens, W., Seftor, R. E. B., Tomita, T., Crispino, J., Miller, R. J., Bohn, M. C., Hendrix, M. J. C. & Soares, M. B., Jan 25 2014, In : Gene. 534, 2, p. 400-407 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Osteoarthritis joint pain: The cytokine connection

Miller, R. E., Miller, R. J. & Malfait, A. M., Dec 1 2014, In : Cytokine. 70, 2, p. 185-193 9 p.

Research output: Contribution to journalReview article

90 Scopus citations

Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: A link to chemokines?

Freitag, C. M. & Miller, R. J., Aug 20 2014, In : Frontiers in Cellular Neuroscience. 8, AUG, 238.

Research output: Contribution to journalReview article

28 Scopus citations
84 Scopus citations

Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells

Somasundaram, A., Shum, A. K., McBride, H. J., Kessler, J. A., Feske, S., Miller, R. J. & Prakriya, M., 2014, In : Journal of Neuroscience. 34, 27, p. 9107-9123 17 p.

Research output: Contribution to journalArticle

71 Scopus citations
2013

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons

Dryanovski, D. I., Guzman, J. N., Xie, Z., Galteri, D. J., Volpicelli-Daley, L. A., Lee, V. M. Y., Miller, R. J., Schumacker, P. T. & James Surmeier, D., Jun 17 2013, In : Journal of Neuroscience. 33, 24, p. 10154-10164 11 p.

Research output: Contribution to journalArticle

110 Scopus citations

CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development

Mithal, D. S., Ren, D. & Miller, R. J., Aug 1 2013, In : Glia. 61, 8, p. 1288-1305 18 p.

Research output: Contribution to journalArticle

22 Scopus citations

Pathogenesis of neonatal herpes simplex 2 disease in a mouse model is dependent on entry receptor expression and route of inoculation

Kopp, S. J., Karaba, A. H., Cohen, L. K., Banisadr, G., Miller, R. J. & Muller, W. J., Jan 1 2013, In : Journal of virology. 87, 1, p. 474-481 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair

Ardelt, A. A., Bhattacharyya, B. J., Belmadani, A., Ren, D. & Miller, R. J., Oct 1 2013, In : Experimental Neurology. 248, p. 246-253 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

The cannabis conundrum

Miller, R. J., Oct 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 43, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2012

Abnormalities in hippocampal functioning with persistent pain

Mutso, A. A., Radzicki, D., Baliki, M. N., Huang, L., Banisadr, G., Centeno, M. V., Radulovic, J., Martina, M., Miller, R. J. & Vania Apkarian, A., Apr 25 2012, In : Journal of Neuroscience. 32, 17, p. 5747-5756 10 p.

Research output: Contribution to journalArticle

218 Scopus citations

Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14

Bhattacharyya, B. J., Wilson, S. M., Jung, H. & Miller, R. J., Feb 2012, In : American Journal of Physiology - Cell Physiology. 302, 4, p. C698-C708

Research output: Contribution to journalArticle

20 Scopus citations

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

Miller, R. E., Tran, P. B., Das, R., Ghoreishi-Haack, N., Ren, D., Miller, R. J. & Malfait, A. M., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20602-20607 6 p.

Research output: Contribution to journalArticle

122 Scopus citations

CXCL12 signaling in the development of the nervous system

Mithal, D. S., Banisadr, G. & Miller, R. J., Dec 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 4, p. 820-834 15 p.

Research output: Contribution to journalReview article

30 Scopus citations