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  • Brian M Hoffman
2020
Open Access

Reduction of substrates by nitrogenases

Seefeldt, L. C., Yang, Z. Y., Lukoyanov, D. A., Harris, D. F., Dean, D. R., Raugei, S. & Hoffman, B. M., Jan 1 2020, (Accepted/In press) In : Chemical Reviews.

Research output: Contribution to journalArticle

The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States

Offenbacher, A. R., Sharma, A., Doan, P. E., Klinman, J. P. & Hoffman, B. M., Jan 1 2020, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

2019

Formation and Electronic Structure of an Atypical CuA Site

Ross, M. O., Fisher, O. S., Morgada, M. N., Krzyaniak, M. D., Wasielewski, M. R., Vila, A. J., Hoffman, B. M. & Rosenzweig, A. C., Mar 20 2019, In : Journal of the American Chemical Society. 141, 11, p. 4678-4686 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

High-Resolution ENDOR Spectroscopy Combined with Quantum Chemical Calculations Reveals the Structure of Nitrogenase Janus Intermediate E4(4H)

Hoeke, V., Tociu, L., Case, D. A., Seefeldt, L. C., Raugei, S. & Hoffman, B. M., Jul 31 2019, In : Journal of the American Chemical Society. 141, 30, p. 11984-11996 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Manganese co-localizes with calcium and phosphorus in Chlamydomonas acidocalcisomes and is mobilized in manganese-deficient conditions

Tsednee, M., Castruita, M., Salomé, P. A., Sharma, A., Lewis, B. E., Schmollinger, S. R., Strenkert, D., Holbrook, K., Otegui, M. S., Khatua, K., Das, S., Datta, A., Chen, S., Ramon, C., Ralle, M., Weber, P. K., Stemmler, T. L., Pett-Ridge, J., Hoffman, B. M. & Merchant, S. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 46, p. 17626-17641 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MbnH is a diheme MauG-like protein associated with microbial copper homeostasis

Kenney, G. E., Dassama, L. M. K., Manesis, A. C., Ross, M. O., Chen, S., Hoffman, B. M. & Rosenzweig, A. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 44, p. 16141-16151 11 p.

Research output: Contribution to journalArticle

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism to Achieve N2 Reduction

Harris, D. F., Lukoyanov, D. A., Kallas, H., Trncik, C., Yang, Z. Y., Compton, P. D., Kelleher, N. L., Einsle, O., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Jul 30 2019, In : Biochemistry. 58, 30, p. 3293-3301 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Particulate methane monooxygenase contains only mononuclear copper centers

Ross, M. O., MacMillan, F., Wang, J., Nisthal, A., Lawton, T. J., Olafson, B. D., Mayo, S. L., Rosenzweig, A. C. & Hoffman, B. M., Jan 1 2019, In : Science. 364, 6440, p. 566-570 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

PCuAC domains from methane-oxidizing bacteria use a histidine brace to bind copper

Fisher, O. S., Sendzik, M. R., Ross, M. O., Lawton, T. J., Hoffman, B. M. & Rosenzweig, A. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 44, p. 16351-16353 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical

Yang, H., Impano, S., Shepard, E. M., James, C. D., Broderick, W. E., Broderick, J. B. & Hoffman, B. M., Oct 9 2019, In : Journal of the American Chemical Society. 141, 40, p. 16117-16124 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase

Davydov, R. M., Jennings, G., Hoffman, B. M. & Podust, L. M., Sep 30 2019, In : Archives of biochemistry and biophysics. 673, 108080.

Research output: Contribution to journalArticle

Spectroscopic Description of the E1 State of Mo Nitrogenase Based on Mo and Fe X-ray Absorption and Mössbauer Studies

Van Stappen, C., Davydov, R., Yang, Z. Y., Fan, R., Guo, Y., Bill, E., Seefeldt, L. C., Hoffman, B. M. & Debeer, S., Sep 16 2019, In : Inorganic chemistry. 58, 18, p. 12365-12376 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

Yang, H., McDaniel, E. C., Impano, S., Byer, A. S., Jodts, R. J., Yokoyama, K., Broderick, W. E., Broderick, J. B. & Hoffman, B. M., Jul 31 2019, In : Journal of the American Chemical Society. 141, 30, p. 12139-12146 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Time-Resolved EPR Study of H2 Reductive Elimination from the Photoexcited Nitrogenase Janus E4(4H) Intermediate

Lukoyanov, D. A., Krzyaniak, M. D., Dean, D. R., Wasielewski, M. R., Seefeldt, L. C. & Hoffman, B. M., Oct 17 2019, In : Journal of Physical Chemistry B. 123, 41, p. 8823-8828 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A structurally-characterized peroxomanganese(IV) porphyrin from reversible O2 binding within a metal-organic framework

Gallagher, A. T., Lee, J. Y., Kathiresan, V., Anderson, J. S., Hoffman, B. M. & Harris, T. D., Jan 1 2018, In : Chemical Science. 9, 6, p. 1596-1603 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Beyond fossil fuel–driven nitrogen transformations

Chen, J. G., Crooks, R. M., Seefeldt, L. C., Bren, K. L., Morris Bullock, R., Darensbourg, M. Y., Holland, P. L., Hoffman, B., Janik, M. J., Jones, A. K., Kanatzidis, M. G., King, P., Lancaster, K. M., Lymar, S. V., Pfromm, P., Schneider, W. F. & Schrock, R. R., May 25 2018, In : Science. 360, 6391, eaar6611.

Research output: Contribution to journalReview article

185 Scopus citations

Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria

Fisher, O. S., Kenney, G. E., Ross, M. O., Ro, S. Y., Lemma, B. E., Batelu, S., Thomas, P. M., Sosnowski, V. C., DeHart, C. J., Kelleher, N. L., Stemmler, T. L., Hoffman, B. M. & Rosenzweig, A. C., Dec 1 2018, In : Nature communications. 9, 1, 4276.

Research output: Contribution to journalArticle

12 Scopus citations

Control of electron transfer in nitrogenase

Seefeldt, L. C., Peters, J. W., Beratan, D. N., Bothner, B., Minteer, S. D., Raugei, S. & Hoffman, B. M., Dec 2018, In : Current Opinion in Chemical Biology. 47, p. 54-59 6 p.

Research output: Contribution to journalReview article

9 Scopus citations
32 Scopus citations

Cu+-specific CopB transporter: Revising p1B-type ATPase classification

Purohit, R., Ross, M. O., Batelu, S., Kusowski, A., Stemmler, T. L., Hoffman, B. M. & Rosenzweig, A. C., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2108-2113 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

ENDOR Characterization of (N2)FeII(μ-H)2FeI(N2)-: A Spectroscopic Model for N2 Binding by the Di-μ-hydrido Nitrogenase Janus Intermediate

Yang, H., Rittle, J., Marts, A. R., Peters, J. C. & Hoffman, B. M., Oct 1 2018, In : Inorganic chemistry. 57, 19, p. 12323-12330 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Energy Transduction in Nitrogenase

Seefeldt, L. C., Hoffman, B. M., Peters, J. W., Raugei, S., Beratan, D. N., Antony, E. & Dean, D. R., Sep 18 2018, In : Accounts of chemical research. 51, 9, p. 2179-2186 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

From micelles to bicelles: Effect of the membrane on particulate methane monooxygenase activity

Ro, S. Y., Ross, M. O., Deng, Y. W., Batelu, S., Lawton, T. J., Hurley, J. D., Stemmler, T. L., Hoffman, B. M. & Rosenzweig, A. C., Jan 1 2018, In : Journal of Biological Chemistry. 293, 27, p. 10457-10465 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hydride Conformers of the Nitrogenase FeMo-cofactor Two-Electron Reduced State E2(2H), Assigned Using Cryogenic Intra Electron Paramagnetic Resonance Cavity Photolysis

Lukoyanov, D. A., Khadka, N., Yang, Z. Y., Dean, D. R., Seefeldt, L. C. & Hoffman, B. M., Jun 18 2018, In : Inorganic chemistry. 57, 12, p. 6847-6852 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Isolation and characterization of a high-spin mixed-valent iron dinitrogen complex

McWilliams, S. F., Bunting, P. C., Kathiresan, V., Mercado, B. Q., Hoffman, B. M., Long, J. R. & Holland, P. L., Jan 1 2018, In : Chemical Communications. 54, 95, p. 13339-13342 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Kinetic Understanding of N2 Reduction versus H2 Evolution at the E4(4H) Janus State in the Three Nitrogenases

Harris, D. F., Yang, Z. Y., Dean, D. R., Seefeldt, L. C. & Hoffman, B. M., Oct 2 2018, In : Biochemistry. 57, 39, p. 5706-5714 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2

Harris, D. F., Lukoyanov, D. A., Shaw, S., Compton, P., Tokmina-Lukaszewska, M., Bothner, B., Kelleher, N., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Feb 6 2018, In : Biochemistry. 57, 5, p. 701-710 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mechanism of Radical Initiation in the Radical S-Adenosyl-L-methionine Superfamily

Broderick, W. E., Hoffman, B. M. & Broderick, J. B., Nov 20 2018, In : Accounts of chemical research. 51, 11, p. 2611-2619 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

Dong, M., Kathiresan, V., Fenwick, M. K., Torelli, A. T., Zhang, Y., Caranto, J. D., Dzikovski, B., Sharma, A., Lancaster, K. M., Freed, J. H., Ealick, S. E., Hoffman, B. M. & Lin, H., Mar 16 2018, In : Science. 359, 6381, p. 1247-1250 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Paradigm Shift for Radical S-Adenosyl- l -methionine Reactions: The Organometallic Intermediate ω Is Central to Catalysis

Byer, A. S., Yang, H., McDaniel, E. C., Kathiresan, V., Impano, S., Pagnier, A., Watts, H., Denler, C., Vagstad, A. L., Piel, J., Duschene, K. S., Shepard, E. M., Shields, T. P., Scott, L. G., Lilla, E. A., Yokoyama, K., Broderick, W. E., Hoffman, B. M. & Broderick, J. B., Jul 18 2018, In : Journal of the American Chemical Society. 140, 28, p. 8634-8638 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
2017

13C ENDOR spectroscopy of lipoxygenase-substrate complexes reveals the structural basis for C-H activation by tunneling

Horitani, M., Offenbacher, A. R., Marcus Carr, C. A., Yu, T., Hoeke, V., Cutsail, G. E., Hammes-Schiffer, S., Klinman, J. P. & Hoffman, B. M., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 1984-1997 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Across the tree of life, radiation resistance is governed by antioxidant Mn2+, gauged by paramagnetic resonance

Sharma, A., Gaidamakova, E. K., Grichenko, O., Matrosova, V. Y., Hoeke, V., Klimenkova, P., Conze, I. H., Volpe, R. P., Tkavc, R., Gostinčar, C., Gunde-Cimerman, N., DiRuggiero, J., Shuryak, I., Ozarowski, A., Hoffman, B. M. & Daly, M. J., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. E9253-E9260

Research output: Contribution to journalArticle

31 Scopus citations

Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice

Kandela, I. K., McAuliffe, K. J., Cochran, L. E., Barrett, A. G. M., Hoffman, B. M., Mazar, A. P. & Trivedi, E. R., Jul 13 2017, In : ACS Medicinal Chemistry Letters. 8, 7, p. 705-709 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

ENDOR characterization of an iron-alkene complex provides insight into a corresponding organometallic intermediate of nitrogenase

Horitani, M., Grubel, K., McWilliams, S. F., Stubbert, B. D., Mercado, B. Q., Yu, Y., Gurubasavaraj, P. M., Lees, N. S., Holland, P. L. & Hoffman, B. M., Jan 1 2017, In : Chemical Science. 8, 9, p. 5941-5948 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Engineered ferritin nanocages as natural contrast agents in magnetic resonance imaging

Nandwana, V., Ryoo, S. R., Kanthala, S., Kumar, A., Sharma, A., Castro, F. C., Li, Y., Hoffman, B., Lim, S. & Dravid, V. P., Jan 1 2017, In : RSC Advances. 7, 55, p. 34892-34900 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

EPR/ENDOR and Theoretical Study of the Jahn-Teller-Active [HIPTN3N]MoVL Complexes (L = N-, NH)

Sharma, A., Roemelt, M., Reithofer, M., Schrock, R. R., Hoffman, B. M. & Neese, F., Jun 19 2017, In : Inorganic chemistry. 56, 12, p. 6906-6919 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects

Khadka, N., Milton, R. D., Shaw, S., Lukoyanov, D., Dean, D. R., Minteer, S. D., Raugei, S., Hoffman, B. M. & Seefeldt, L. C., Jan 1 2017, In : Journal of the American Chemical Society. 139, 38, p. 13518-13524 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Metal selectivity of a Cd-, Co-, and Zn-transporting P1B-type ATPase

Smith, A. T., Ross, M. O., Hoffman, B. M. & Rosenzweig, A. C., Jan 1 2017, In : Biochemistry. 56, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

Shisler, K. A., Hutcheson, R. U., Horitani, M., Duschene, K. S., Crain, A. V., Byer, A. S., Shepard, E. M., Rasmussen, A., Yang, J., Broderick, W. E., Vey, J. L., Drennan, C. L., Hoffman, B. M. & Broderick, J. B., Aug 30 2017, In : Journal of the American Chemical Society. 139, 34, p. 11803-11813 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nitrogenase Mechanism: Electron and Proton Accumulation and N2 Reduction

Seefeldt, L. C., Dean, D. R. & Hoffman, B. M., Jan 1 2017, Molybdenum and Tungsten Enzymes: Biochemistry. Garner, C. D., Hille, R., Schulzke, C. & Kirk, M. L. (eds.). 5 ed. Royal Society of Chemistry, p. 274-296 23 p. (RSC Metallobiology; vol. 2017-January, no. 5).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Photoinduced Reductive Elimination of H2 from the Nitrogenase Dihydride (Janus) State Involves a FeMo-cofactor-H2 Intermediate

Lukoyanov, D., Khadka, N., Dean, D. R., Raugei, S., Seefeldt, L. C. & Hoffman, B. M., Feb 20 2017, In : Inorganic chemistry. 56, 4, p. 2233-2240 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis

Dong, M., Horitani, M., Dzikovski, B., Freed, J. H., Ealick, S. E., Hoffman, B. M. & Lin, H., Apr 26 2017, In : Journal of the American Chemical Society. 139, 16, p. 5680-5683 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Characterization of Methanobactin from Methylosinus sp. LW4

Kenney, G. E., Goering, A. W., Ross, M. O., DeHart, C. J., Thomas, P. M., Hoffman, B. M., Kelleher, N. L. & Rosenzweig, A. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11124-11127 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Charge-Disproportionation Symmetry Breaking Creates a Heterodimeric Myoglobin Complex with Enhanced Affinity and Rapid Intracomplex Electron Transfer

Trana, E. N., Nocek, J. M., Woude, J. V., Span, I., Smith, S. M., Rosenzweig, A. C. & Hoffman, B. M., Sep 28 2016, In : Journal of the American Chemical Society. 138, 38, p. 12615-12628 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

CO2 Reduction Catalyzed by Nitrogenase: Pathways to Formate, Carbon Monoxide, and Methane

Khadka, N., Dean, D. R., Smith, D., Hoffman, B. M., Raugei, S. & Seefeldt, L. C., Sep 6 2016, In : Inorganic chemistry. 55, 17, p. 8321-8330 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Comparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction Studies

Davydov, R., Fleischhacker, A. S., Bagai, I., Hoffman, B. M. & Ragsdale, S. W., Jan 19 2016, In : Biochemistry. 55, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Exploring Electron/Proton Transfer and Conformational Changes in the Nitrogenase MoFe Protein and FeMo-cofactor Through Cryoreduction/EPR Measurements

Davydov, R., Khadka, N., Yang, Z. Y., Fielding, A. J., Lukoyanov, D., Dean, D. R., Seefeldt, L. C. & Hoffman, B. M., Oct 1 2016, In : Israel Journal of Chemistry. 56, 9-10, p. 841-851 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Imaging ultrafast excited state pathways in transition metal complexes by X-ray transient absorption and scattering using X-ray free electron laser source

Chen, L. X., Shelby, M. L., Lestrange, P. J., Jackson, N. E., Haldrup, K., Mara, M. W., Stickrath, A. B., Zhu, D., Lemke, H., Chollet, M., Hoffman, B. M. & Li, X., Jan 1 2016, In : Faraday Discussions. 194, p. 639-658 20 p.

Research output: Contribution to journalArticle

5 Scopus citations

Metalloproteins: Radical SAM catalysis via an organometallic intermediate with an Fe-[5′-C]-deoxyadenosyl bond

Horitani, M., Shisler, K., Broderick, W. E., Hutcheson, R. U., Duschene, K. S., Marts, A. R., Hoffman, B. M. & Broderick, J. B., May 13 2016, In : Science. 352, 6287, p. 822-825 4 p.

Research output: Contribution to journalArticle

38 Scopus citations