Aβ oligomer-induced synapse degeneration in Alzheimer's disease.

Kyle C. Wilcox*, Pascale N. Lacor, Jason Pitt, William L. Klein

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


Aβ oligomers cause a collection of molecular events associated with memory loss in Alzheimer's disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of Aβ oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity-especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)939-948
Number of pages10
JournalCellular and molecular neurobiology
Issue number6
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


Dive into the research topics of 'Aβ oligomer-induced synapse degeneration in Alzheimer's disease.'. Together they form a unique fingerprint.

Cite this