A 17-Gene Panel Genomic Prostate Score Has Similar Predictive Accuracy for Adverse Pathology at Radical Prostatectomy in African American and European American Men

Adam B. Murphy*, Samuel Carbunaru, Oluwarotimi S. Nettey, Chase Gornbein, Virgilia Macias, Roohollah Sharifi, Rick A. Kittles, Ximing Yang, Andre Kajdacsy-Balla, Peter Gann, Michael A. Dixon

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Objective: To validate the 17-gene Oncotype DX Genomic Prostate Score (GPS) as a predictor of adverse pathology (AP) in African American (AA) men and to assess the distribution of GPS in AA and European American (EA) men with localized prostate cancer. Methods: The study populations were derived from 2 multi-institutional observational studies. Between February 2009 and September 2014, AA and EA men who elected immediate radical prostatectomy after a ≥10-core transrectal ultrasound biopsy were included in the study. Logistic regressions, area under the receiver operating characteristics curves (AUC), calibration curves, and predictive values were used to compare the accuracy of GPS. AP was defined as primary Gleason grade 4, presence of any Gleason pattern 5, and/or non-organ-confined disease (≥pT3aN0M0) at radical prostatectomy. Results: Overall, 96 AA and 76 EA men were selected and 46 (26.7%) had AP. GPS result was a significant predictor of AP (odds ratio per 20 GPS units [OR/20 units] in AA: 4.58; 95% confidence interval (CI) 1.8-11.5, P = .001; and EA: 4.88; 95% CI 1.8-13.5, P = .002). On multivariate analysis, there was no significant interaction between GPS and race (P >.10). GPS remained significant in models adjusted for either National Comprehensive Cancer Network (NCCN) risk group or Cancer of the Prostate Risk Assessment (CAPRA) score. In race-stratified models, area under the receiver operating characteristics curves for GPS/20 units was 0.69 for AAs vs 0.74 for EAs (P = .79). The GPS distributions were not statistically different by race (all P >.05). Conclusion: In this clinical validation study, the Oncotype DX GPS is an independent predictor of AP at prostatectomy in AA and EA men with similar predictive accuracy and distributions.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalUrology
Volume142
DOIs
StatePublished - Aug 2020

ASJC Scopus subject areas

  • Urology

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    Murphy, A. B., Carbunaru, S., Nettey, O. S., Gornbein, C., Macias, V., Sharifi, R., Kittles, R. A., Yang, X., Kajdacsy-Balla, A., Gann, P., & Dixon, M. A. (2020). A 17-Gene Panel Genomic Prostate Score Has Similar Predictive Accuracy for Adverse Pathology at Radical Prostatectomy in African American and European American Men. Urology, 142, 166-173. https://doi.org/10.1016/j.urology.2020.01.052