A 6 week randomized double-blind placebo-controlled trial of ziprasidone for the acute depressive mixed state

Ashwin Patkar, William Gilmer, Chi un Pae, Paul A. Vöhringer, Michael Ziffra, Edward Pirok, Molly Mulligan, Megan M. Filkowski, Elizabeth A. Whitham, Niki S. Holtzman, Sairah B. Thommi, Tanya Logvinenko, Antony Loebel, Prakash Masand, S. Nassir Ghaemi

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Objective: To examine the efficacy of ziprasidone vs. placebo for the depressive mixed state in patients with bipolar disorder type II or major depressive disorder (MDD). Methods: 73 patients were randomized in a double-blinded, placebo-controlled study to ziprasidone (40-160 mg/d) or placebo for 6 weeks. They met DSM-IV criteria for a major depressive episode (MDE), while also meeting 2 or 3 (but not more nor less) DSM-IV manic criteria. They did not meet DSM-IV criteria for a mixed or manic episode. Baseline psychotropic drugs were continued unchanged. The primary endpoint measured was Montgomery- Åsberg Depression Rating Scale (MADRS) scores over time. The mean dose of ziprasidone was 129.7±45.3 mg/day and 126.1±47.1 mg/day for placebo. Results: The primary outcome analysis indicated efficacy of ziprasidone versus placebo (p = 0.0038). Efficacy was more pronounced in type II bipolar disorder than in MDD (p = 0.036). Overall ziprasidone was well tolerated, without notable worsening of weight or extrapyramidal symptoms. Conclusions: There was a statistically significant benefit with ziprasidone versus placebo in this first RCT of any medication for the provisional diagnostic concept of the depressive mixed state.

Original languageEnglish (US)
Article numbere34757
JournalPloS one
Issue number4
StatePublished - Apr 24 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'A 6 week randomized double-blind placebo-controlled trial of ziprasidone for the acute depressive mixed state'. Together they form a unique fingerprint.

Cite this