A 6.5-Mb Yeast Artificial Chromosome Contig Incorporating 33 DNA Markers on the Human X Chromosome at Xq22

David Vetrie*, Elaine Kendall, Alison Coffey, Sheila Hassock, John Collins, Chris Todd, Hans Lehrach, Martin Bobrow, David R. Bentley, Ann Harris

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalGenomics
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Genetics

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