A bacterial siren song: Intimate interactions between Neisseria and neutrophils

Alison K. Criss*, H. Steven Seifert

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative bacterial pathogens that are exquisitely adapted for growth at human mucosal surfaces and for efficient transmission between hosts. One factor that is essential to neisserial pathogenesis is the interaction between the bacteria and neutrophils, which are recruited in high numbers during infection. Although this vigorous host response could simply reflect effective immune recognition of the bacteria, there is mounting evidence that in fact these obligate human pathogens manipulate the innate immune response to promote infectious processes. This Review summarizes the mechanisms used by pathogenic neisseriae to resist and modulate the antimicrobial activities of neutrophils. It also details some of the major outstanding questions about the Neisseria-neutrophil relationship and proposes potential benefits of this relationship for the pathogen.

Original languageEnglish (US)
Pages (from-to)178-190
Number of pages13
JournalNature Reviews Microbiology
Issue number3
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases


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