A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature

Kyeongha Kwon; Jong Uk Kim; Sang Min Won; Jianzhong Zhao; Raudel Avila; Heling Wang; Keum San Chun; Hokyung Jang; Kun Hyuck Lee; Jae Hwan Kim; Seonggwang Yoo; Youn J. Kang; Joohee Kim; Jaeman Lim; Yoonseok Park; Wei Lu; Tae il Kim; Anthony Banks; Yonggang Huang; John A. Rogers

doi:10.1038/s41551-023-01022-4

A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature

Kyeongha Kwon^*, Jong Uk Kim, Sang Min Won, Jianzhong Zhao, Raudel Avila, Heling Wang, Keum San Chun, Hokyung Jang, Kun Hyuck Lee, Jae Hwan Kim, Seonggwang Yoo, Youn J. Kang, Joohee Kim, Jaeman Lim, Yoonseok Park, Wei Lu, Tae il Kim, Anthony Banks, Yonggang Huang, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Devices for monitoring blood haemodynamics can guide the perioperative management of patients with cardiovascular disease. Current technologies for this purpose are constrained by wired connections to external electronics, and wireless alternatives are restricted to monitoring of either blood pressure or blood flow. Here we report the design aspects and performance parameters of an integrated wireless sensor capable of implantation in the heart or in a blood vessel for simultaneous measurements of pressure, flow rate and temperature in real time. The sensor is controlled via long-range communication through a subcutaneously implanted and wirelessly powered Bluetooth Low Energy system-on-a-chip. The device can be delivered via a minimally invasive transcatheter procedure or it can be mounted on a passive medical device such as a stent, as we show for the case of the pulmonary artery in a pig model and the aorta and left ventricle in a sheep model, where the device performs comparably to clinical tools for monitoring of blood flow and pressure. Battery-less and wireless devices such as these that integrate capabilities for flow, pressure and temperature sensing offer the potential for continuous monitoring of blood haemodynamics in patients.

Original language	English (US)
Pages (from-to)	1215-1228
Number of pages	14
Journal	Nature Biomedical Engineering
Volume	7
Issue number	10
DOIs	https://doi.org/10.1038/s41551-023-01022-4
State	Published - Oct 2023

Funding

K.K. acknowledges support by the National Research Foundation (NRF) grant funded by the Korea government (MSIP; Ministry of Science, ICT & Future Planning; no. 2021R1F1A106387111, no. 2022R1C1C1010555 and no. 2020R1A5A8018367). J.U.K. and T.K. were supported by the NRF funded by the Korean government (MSIT; NRF-2019M3C7A1032076 and NRF-2020M3H4A1A03082897). S.M.W. acknowledges support by the NRF grant funded by the Korea government (MSIP, ICT & Future Planning; no. NRF-2021R1C1C1009410 and no. IITP-2020-0-01821). R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF grant number DGE-1842165) and Ford Foundation Predoctoral Fellowship. J.A.R. acknowledges support from the National Institute on Aging of the National Institutes of Health (NIH R43AG067835). We acknowledge funding from Wearifi Inc., and the Querrey-Simpson Institute for Bioelectronics at Northwestern University for support of this work. This work made use of the NUFAB facility of Northwestern University\u2019s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the MRSEC programme (NSF DMR-1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation and the State of Illinois, through the IIN.

ASJC Scopus subject areas

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41551-023-01022-4

Cite this

Kwon, K., Kim, J. U., Won, S. M., Zhao, J., Avila, R., Wang, H., Chun, K. S., Jang, H., Lee, K. H., Kim, J. H., Yoo, S., Kang, Y. J., Kim, J., Lim, J., Park, Y., Lu, W., Kim, T. I., Banks, A., Huang, Y., & Rogers, J. A. (2023). A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature. Nature Biomedical Engineering, 7(10), 1215-1228. https://doi.org/10.1038/s41551-023-01022-4

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abstract = "Devices for monitoring blood haemodynamics can guide the perioperative management of patients with cardiovascular disease. Current technologies for this purpose are constrained by wired connections to external electronics, and wireless alternatives are restricted to monitoring of either blood pressure or blood flow. Here we report the design aspects and performance parameters of an integrated wireless sensor capable of implantation in the heart or in a blood vessel for simultaneous measurements of pressure, flow rate and temperature in real time. The sensor is controlled via long-range communication through a subcutaneously implanted and wirelessly powered Bluetooth Low Energy system-on-a-chip. The device can be delivered via a minimally invasive transcatheter procedure or it can be mounted on a passive medical device such as a stent, as we show for the case of the pulmonary artery in a pig model and the aorta and left ventricle in a sheep model, where the device performs comparably to clinical tools for monitoring of blood flow and pressure. Battery-less and wireless devices such as these that integrate capabilities for flow, pressure and temperature sensing offer the potential for continuous monitoring of blood haemodynamics in patients.",

author = "Kyeongha Kwon and Kim, {Jong Uk} and Won, {Sang Min} and Jianzhong Zhao and Raudel Avila and Heling Wang and Chun, {Keum San} and Hokyung Jang and Lee, {Kun Hyuck} and Kim, {Jae Hwan} and Seonggwang Yoo and Kang, {Youn J.} and Joohee Kim and Jaeman Lim and Yoonseok Park and Wei Lu and Kim, {Tae il} and Anthony Banks and Yonggang Huang and Rogers, {John A.}",

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Kwon, K, Kim, JU, Won, SM, Zhao, J, Avila, R, Wang, H, Chun, KS, Jang, H, Lee, KH, Kim, JH, Yoo, S, Kang, YJ, Kim, J, Lim, J, Park, Y, Lu, W, Kim, TI, Banks, A, Huang, Y & Rogers, JA 2023, 'A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature', Nature Biomedical Engineering, vol. 7, no. 10, pp. 1215-1228. https://doi.org/10.1038/s41551-023-01022-4

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AU - Wang, Heling

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AU - Lim, Jaeman

AU - Park, Yoonseok

AU - Lu, Wei

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AU - Banks, Anthony

AU - Huang, Yonggang

AU - Rogers, John A.

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AB - Devices for monitoring blood haemodynamics can guide the perioperative management of patients with cardiovascular disease. Current technologies for this purpose are constrained by wired connections to external electronics, and wireless alternatives are restricted to monitoring of either blood pressure or blood flow. Here we report the design aspects and performance parameters of an integrated wireless sensor capable of implantation in the heart or in a blood vessel for simultaneous measurements of pressure, flow rate and temperature in real time. The sensor is controlled via long-range communication through a subcutaneously implanted and wirelessly powered Bluetooth Low Energy system-on-a-chip. The device can be delivered via a minimally invasive transcatheter procedure or it can be mounted on a passive medical device such as a stent, as we show for the case of the pulmonary artery in a pig model and the aorta and left ventricle in a sheep model, where the device performs comparably to clinical tools for monitoring of blood flow and pressure. Battery-less and wireless devices such as these that integrate capabilities for flow, pressure and temperature sensing offer the potential for continuous monitoring of blood haemodynamics in patients.

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A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature

Abstract

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ASJC Scopus subject areas

UN SDGs

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