A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature

Kyeongha Kwon*, Jong Uk Kim, Sang Min Won, Jianzhong Zhao, Raudel Avila, Heling Wang, Keum San Chun, Hokyung Jang, Kun Hyuck Lee, Jae Hwan Kim, Seonggwang Yoo, Youn J. Kang, Joohee Kim, Jaeman Lim, Yoonseok Park, Wei Lu, Tae il Kim, Anthony Banks, Yonggang Huang, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Devices for monitoring blood haemodynamics can guide the perioperative management of patients with cardiovascular disease. Current technologies for this purpose are constrained by wired connections to external electronics, and wireless alternatives are restricted to monitoring of either blood pressure or blood flow. Here we report the design aspects and performance parameters of an integrated wireless sensor capable of implantation in the heart or in a blood vessel for simultaneous measurements of pressure, flow rate and temperature in real time. The sensor is controlled via long-range communication through a subcutaneously implanted and wirelessly powered Bluetooth Low Energy system-on-a-chip. The device can be delivered via a minimally invasive transcatheter procedure or it can be mounted on a passive medical device such as a stent, as we show for the case of the pulmonary artery in a pig model and the aorta and left ventricle in a sheep model, where the device performs comparably to clinical tools for monitoring of blood flow and pressure. Battery-less and wireless devices such as these that integrate capabilities for flow, pressure and temperature sensing offer the potential for continuous monitoring of blood haemodynamics in patients.

Original languageEnglish (US)
Pages (from-to)1215-1228
Number of pages14
JournalNature Biomedical Engineering
Volume7
Issue number10
DOIs
StatePublished - Oct 2023

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Computer Science Applications

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