Abstract
While titanium has been clinically successful as an orthopedic or dental implant material, performance problems still persist related to implant-bone interfacial strength and mechanical modulus mismatch between titanium and tissue. We describe here the preparation of a titanium foam as a better mechanical match to tissue with surfaces attractive to bone cells through deposition of an organically-modified apatite layer (organoapatite). In a rotating bioreactor, these organoapatite-coated foams are successfully colonized by preosteoblastic cells. Finite element analyses suggest that ingrown tissue in these systems may improve both implant performance and tissue formation through load-sharing and stress distribution. The novel metal-ceramic-polymer hybrid materials described here hold great promise for bone tissue engineering.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 523-533 |
| Number of pages | 11 |
| Journal | Acta Biomaterialia |
| Volume | 1 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2005 |
Funding
We would like to gratefully acknowledge funding support from the National Science Foundation (DMR0108342) and the Department of Energy (DEFG02-00ER45810). We would also like to acknowledge Professor Lonnie Shea in the Northwestern University Department of Chemical Engineering for donation of the MC3T3-E1 cell line.
Keywords
- Bioreactor
- Finite element model
- Hydroxyapatite
- Organoapatite
- Osteoblasts
- Porous titanium
- Stress-shielding
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Biotechnology
- Biomedical Engineering
- Biomaterials