Abstract
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability. (Figure presented.).
Original language | English (US) |
---|---|
Pages (from-to) | 1131-1137 |
Number of pages | 7 |
Journal | Advanced Synthesis and Catalysis |
Volume | 359 |
Issue number | 7 |
DOIs | |
State | Published - Apr 3 2017 |
Keywords
- asymmetric synthesis
- enzyme catalysis
- hydroxydioxinones
- ketoreductases
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry