A biomechanical approach to musculoskeletal disease

Najia Shakoor*, Kirsten Moisio

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The importance of biomechanical factors in musculoskeletal disease may be appreciated in the clinical characteristics and pathophysiology of joint degeneration in osteoarthritis. The biomechanical characteristics of the neuromuscular system are integral in determining the function and stability of the synovial joint and in mediating the biochemical structure of articular cartilage. Alterations in the neuromuscular system including abnormal gait and dynamic joint loading patterns as well as muscle strength and proprioception deficits have been independently studied and associated with osteoarthritis. These factors have close functional and physiological interactions. Nevertheless, specific relations between muscle strength and proprioception and their independent contributions to dynamic joint loading are not yet clear. Targeted interventions to moderate these factors may, in the future, be a therapeutic option for the management of osteoarthritis.

Original languageEnglish (US)
Pages (from-to)173-186
Number of pages14
JournalBest Practice and Research: Clinical Rheumatology
Issue number2
StatePublished - Apr 2004


  • Biomechanics
  • Dynamic joint loading
  • Muscle strength
  • Osteoarthritis
  • Proprioception

ASJC Scopus subject areas

  • Rheumatology


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