Abstract
(Figure Presented). We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.
Original language | English (US) |
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Pages (from-to) | 98-101 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 2015 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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CCDC 1024173: Experimental Crystal Structure Determination
McDonald, B. R. (Creator), Nibbs, A. E. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc13cqv1, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13cqv1&sid=DataCite
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