A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel

Jian Yang*, Delara Motlagh, Antonio R. Webb, Guillermo Antonio Ameer

*Corresponding author for this work

Research output: Contribution to conferencePaper

Abstract

A biphasic scaffold that recapitulates smooth muscle cell (SMC) compartmentalization in a tissue engineered construct was fabricated. A newly developed biodegradable elastomeric polyester, poly(diol-co-citrate) was investigated for use as a scaffold material. The biphasic scaffold consists of a solid, continuous phase enabling the formation of a monolayer of endothelia cells (EC) within the vessel lumen. The scaffold was subjected to various characterization, including burst pressure as well as co-culture with SMC and EC. The results suggest that a biphasic scaffold design based on poly(diol-co-citrate) is a viable strategy towards the engineering of small diameter blood vessels.

Original languageEnglish (US)
Pages8333-8335
Number of pages3
StatePublished - Dec 1 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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    Yang, J., Motlagh, D., Webb, A. R., & Ameer, G. A. (2004). A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel. 8333-8335. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.