A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed Tomography

Lee Robison, Lin Zhang, Riki J. Drout, Peng Li, Chad R Haney, Anlil Brikha, Hyunho Noh, B. Layla Mehdi, Nigel D. Browning, Vinayak P Dravid, Qun Cui, Timur Islamoglu, Omar k Farha*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new bismuth metal-organic framework (MOF), bismuth-NU-901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ∼11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework's high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates ∼7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ∼14 times better contrast than a commercially available CT contrast agent. These results suggest bismuth MOFs may be promising CT contrast agents.

Original languageEnglish (US)
Pages (from-to)1197-1203
Number of pages7
JournalACS Applied Bio Materials
Volume2
Issue number3
DOIs
StatePublished - Mar 18 2019

Fingerprint

Bismuth
X Ray Computed Tomography
Contrast Media
Tomography
Metals
X rays
Topology
Contrast media
Scanning Transmission Electron Microscopy
Benzoates
Pyrene
Zirconium
Discrete Fourier transforms
X-Ray Diffraction
Powders
X ray powder diffraction
Pore size
Tissue
Transmission electron microscopy
Atoms

Keywords

  • bismuth
  • contrast agent
  • metal-organic frameworks
  • X-ray computed tomography

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

Robison, Lee ; Zhang, Lin ; Drout, Riki J. ; Li, Peng ; Haney, Chad R ; Brikha, Anlil ; Noh, Hyunho ; Mehdi, B. Layla ; Browning, Nigel D. ; Dravid, Vinayak P ; Cui, Qun ; Islamoglu, Timur ; Farha, Omar k. / A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed Tomography. In: ACS Applied Bio Materials. 2019 ; Vol. 2, No. 3. pp. 1197-1203.
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abstract = "A new bismuth metal-organic framework (MOF), bismuth-NU-901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ∼11 {\AA}, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework's high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates ∼7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ∼14 times better contrast than a commercially available CT contrast agent. These results suggest bismuth MOFs may be promising CT contrast agents.",
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author = "Lee Robison and Lin Zhang and Drout, {Riki J.} and Peng Li and Haney, {Chad R} and Anlil Brikha and Hyunho Noh and Mehdi, {B. Layla} and Browning, {Nigel D.} and Dravid, {Vinayak P} and Qun Cui and Timur Islamoglu and Farha, {Omar k}",
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Robison, L, Zhang, L, Drout, RJ, Li, P, Haney, CR, Brikha, A, Noh, H, Mehdi, BL, Browning, ND, Dravid, VP, Cui, Q, Islamoglu, T & Farha, OK 2019, 'A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed Tomography', ACS Applied Bio Materials, vol. 2, no. 3, pp. 1197-1203. https://doi.org/10.1021/acsabm.8b00778

A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed Tomography. / Robison, Lee; Zhang, Lin; Drout, Riki J.; Li, Peng; Haney, Chad R; Brikha, Anlil; Noh, Hyunho; Mehdi, B. Layla; Browning, Nigel D.; Dravid, Vinayak P; Cui, Qun; Islamoglu, Timur; Farha, Omar k.

In: ACS Applied Bio Materials, Vol. 2, No. 3, 18.03.2019, p. 1197-1203.

Research output: Contribution to journalArticle

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T1 - A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed Tomography

AU - Robison, Lee

AU - Zhang, Lin

AU - Drout, Riki J.

AU - Li, Peng

AU - Haney, Chad R

AU - Brikha, Anlil

AU - Noh, Hyunho

AU - Mehdi, B. Layla

AU - Browning, Nigel D.

AU - Dravid, Vinayak P

AU - Cui, Qun

AU - Islamoglu, Timur

AU - Farha, Omar k

PY - 2019/3/18

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N2 - A new bismuth metal-organic framework (MOF), bismuth-NU-901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ∼11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework's high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates ∼7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ∼14 times better contrast than a commercially available CT contrast agent. These results suggest bismuth MOFs may be promising CT contrast agents.

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KW - X-ray computed tomography

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