A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis

Tamanna Haque, Aditi Shastri, Pinkal Desai, Zhuoer Xie, Danielle Hammond, Zoe King, Ashwin Kishtagari, Yazan F. Madanat, Yasmin Abaza, Alexander J. Silver, Abhay Singh, Uma M. Borate, J. Brett Heimlich, David A. Slosky, Kelly L. Bolton, Mrinal S. Patnaik, Alexander G. Bick, Amit K. Verma, Siddhartha Jaiswal, David P. SteensmaMichael R. Savona*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The age-associated mutational state of clonal haematopoiesis (CH) is linked to multiple adverse health outcomes. As higher risk CH can lead to progressive neoplastic or vascular disease, there is interest in developing clinical trials to mitigate risk associated with CH. Given the high prevalence of CH, data from clinical trials could have broad public health implications for screening and therapy. Thoughtful consideration is needed to design trials that are both clinically relevant and avoid overmedicalization. Here, we summarize clinical studies of CH to date and provide suggestions and guidance on how to approach designing CH-focused therapeutic clinical trials. These recommendations are derived from discussions among clinical researchers and scientists emanating from the Inaugural Meeting on Somatic Mutations and Predisease in October 2021.

Original languageEnglish (US)
JournalBritish Journal of Haematology
DOIs
StateAccepted/In press - 2024

Keywords

  • clinical trials
  • clonal cytopenias
  • clonal hematopoiesis
  • therapy

ASJC Scopus subject areas

  • Hematology

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