A Brief Report: IgG and IgE Antibody Responses of Children and Adults Following Polymerized Tree Immunotherapy

Leslie C. Grammer; Martha A. Shaughnessy; Loui Silvestri; Roy Patterson

doi:10.1089/pai.1989.3.41

A Brief Report: IgG and IgE Antibody Responses of Children and Adults Following Polymerized Tree Immunotherapy

Leslie C. Grammer^*, Martha A. Shaughnessy, Loui Silvestri, Roy Patterson

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

Abstract

The IgG and IgE antibody responses to elm and oak tree pollen were analyzed by enzyme-linked immunosorbent assay (ELISA) in 18 children and 12 adults with tree pollinosis. Children and adults had similar initial ELISA titers. After receiving approximately 50,000 protein nitrogen units (PNU) of individually polymerized tree pollen (IPT) allergens in 12 weekly injections, children and adults had similar IgG responses to elm and oak and similar IgE responses to elm. Adults had a slight increase in IgE to oak that was statistically significant when compared with the increase in children (p = 0.02). In general, then, both children and adults have similar changes in IgG and IgE titers to tree pollens after IPT immunotherapy, demonstrating retained immunogenicity of IPT.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Pediatric Asthma, Allergy and Immunology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1089/pai.1989.3.41
State	Published - Jan 1 1989

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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10.1089/pai.1989.3.41

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title = "A Brief Report: IgG and IgE Antibody Responses of Children and Adults Following Polymerized Tree Immunotherapy",

abstract = "The IgG and IgE antibody responses to elm and oak tree pollen were analyzed by enzyme-linked immunosorbent assay (ELISA) in 18 children and 12 adults with tree pollinosis. Children and adults had similar initial ELISA titers. After receiving approximately 50,000 protein nitrogen units (PNU) of individually polymerized tree pollen (IPT) allergens in 12 weekly injections, children and adults had similar IgG responses to elm and oak and similar IgE responses to elm. Adults had a slight increase in IgE to oak that was statistically significant when compared with the increase in children (p = 0.02). In general, then, both children and adults have similar changes in IgG and IgE titers to tree pollens after IPT immunotherapy, demonstrating retained immunogenicity of IPT.",

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AB - The IgG and IgE antibody responses to elm and oak tree pollen were analyzed by enzyme-linked immunosorbent assay (ELISA) in 18 children and 12 adults with tree pollinosis. Children and adults had similar initial ELISA titers. After receiving approximately 50,000 protein nitrogen units (PNU) of individually polymerized tree pollen (IPT) allergens in 12 weekly injections, children and adults had similar IgG responses to elm and oak and similar IgE responses to elm. Adults had a slight increase in IgE to oak that was statistically significant when compared with the increase in children (p = 0.02). In general, then, both children and adults have similar changes in IgG and IgE titers to tree pollens after IPT immunotherapy, demonstrating retained immunogenicity of IPT.

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