A brief symptom index for advanced lung cancer

Susan Yount*, Jennifer Beaumont, Sarah Rosenbloom, David Cella, Jyoti D Patel, Thomas Hensing, Paul B. Jacobsen, Karen Syrjala, Amy P. Abernethy

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Advanced lung cancer is often symptomatic; thus the goals of treatment include maintenance of function and palliation of symptoms. Symptom management requires accurate systematic symptom assessment. This study, which focused on lung cancer, is part of a larger study to obtain patient input that, in combination with previously obtained physician and nurse input, was used to develop symptom indexes for 11 advanced cancers. Fifty patients with advanced lung cancer were recruited from National Comprehensive Cancer Network (NCCN) member institutions and community support agencies; 10 physician experts were recruited from NCCN institutions. Patients reported symptoms associated with their disease in open-ended format and then completed a checklist of symptoms, rating their 5 most important symptoms. Patient and provider ratings of symptom importance were tabulated to construct the NCCN-Functional Assessment of Cancer Therapy (FACT) Lung Symptom Index-17 (NFLSI-17). Patients also completed the Functional Assessment of Cancer Therapy-Lung (FACT-L), which was used to preliminarily validate the NFLSI-17. Based on combined patient, physician, and nurse input, the NFLSI-17 is composed of 17 priority symptoms, 11 that are disease related, 3 that are treatment related, and 3 that are related to general functional well-being (FWB). Data on 15 of 17 NFLSI-17 symptoms showed good internal consistency (alpha = 0.74) and strong association with the FACT-L total and most subscale scores (r = 0.42-0.92). Both the NFLSI-15 (F(2,47) = 4.46; P =.017) and the NFLSI-disease related subscale (DRS) (F(2,47) = 5.56; P =.007) significantly discriminated patients among performance status groups. The NFLSI-17 reflects the most important patient- and clinician-rated targets of chemotherapy for advanced lung cancer; further validation will follow.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalClinical Lung Cancer
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Health-related quality of life
  • Lung cancer
  • Patient-centered
  • Symptom index
  • Symptoms

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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  • Cite this

    Yount, S., Beaumont, J., Rosenbloom, S., Cella, D., Patel, J. D., Hensing, T., Jacobsen, P. B., Syrjala, K., & Abernethy, A. P. (2012). A brief symptom index for advanced lung cancer. Clinical Lung Cancer, 13(1), 14-23. https://doi.org/10.1016/j.cllc.2011.03.033