A B1-insensitive high resolution 2D T1 mapping pulse sequence for dGEMRIC of the HIP at 3 Tesla

Riccardo Lattanzi*, Christian Glaser, Artem V. Mikheev, Catherine Petchprapa, David J. Mossa, Soterios Gyftopoulos, Henry Rusinek, Michael Recht, Daniel Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Early detection of cartilage degeneration in the hip may help prevent onset and progression of osteoarthritis in young patients with femoroacetabular impingement. Delayed gadolinium-enhanced MRI of cartilage is sensitive to cartilage glycosaminoglycan loss and could serve as a diagnostic tool for early cartilage degeneration. We propose a new high resolution 2D T1 mapping saturation-recovery pulse sequence with fast spin echo readout for delayed gadolinium-enhanced magnetic resonance imaging of cartilage of the hip at 3 T. The proposed sequence was validated in a phantom and in 10 hips, using radial imaging planes, against a rigorous multipoint saturation-recovery pulse sequence with fast spin echo readout. T1 measurements by the two pulse sequences were strongly correlated (R2 > 0.95) and in excellent agreement (mean difference = -8.7 ms; upper and lower 95% limits of agreement = 64.5 and -81.9 ms, respectively). T1 measurements were insensitive to B1+ variation as large as 20%, making the proposed T1 mapping technique suitable for 3 T.

Original languageEnglish (US)
Pages (from-to)348-355
Number of pages8
JournalMagnetic resonance in medicine
Volume66
Issue number2
DOIs
StatePublished - Aug 2011

Keywords

  • B inhomogeneity
  • MRI
  • T mapping
  • dGEMRIC
  • femoroacetabular impingement
  • hip, cartilage
  • radial MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Lattanzi, R., Glaser, C., Mikheev, A. V., Petchprapa, C., Mossa, D. J., Gyftopoulos, S., Rusinek, H., Recht, M., & Kim, D. (2011). A B1-insensitive high resolution 2D T1 mapping pulse sequence for dGEMRIC of the HIP at 3 Tesla. Magnetic resonance in medicine, 66(2), 348-355. https://doi.org/10.1002/mrm.23035