A B1-insensitive high resolution 2D T1 mapping pulse sequence for dGEMRIC of the HIP at 3 Tesla

Riccardo Lattanzi*, Christian Glaser, Artem V. Mikheev, Catherine Petchprapa, David J. Mossa, Soterios Gyftopoulos, Henry Rusinek, Michael Recht, Daniel Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Early detection of cartilage degeneration in the hip may help prevent onset and progression of osteoarthritis in young patients with femoroacetabular impingement. Delayed gadolinium-enhanced MRI of cartilage is sensitive to cartilage glycosaminoglycan loss and could serve as a diagnostic tool for early cartilage degeneration. We propose a new high resolution 2D T1 mapping saturation-recovery pulse sequence with fast spin echo readout for delayed gadolinium-enhanced magnetic resonance imaging of cartilage of the hip at 3 T. The proposed sequence was validated in a phantom and in 10 hips, using radial imaging planes, against a rigorous multipoint saturation-recovery pulse sequence with fast spin echo readout. T1 measurements by the two pulse sequences were strongly correlated (R2 > 0.95) and in excellent agreement (mean difference = -8.7 ms; upper and lower 95% limits of agreement = 64.5 and -81.9 ms, respectively). T1 measurements were insensitive to B1+ variation as large as 20%, making the proposed T1 mapping technique suitable for 3 T.

Original languageEnglish (US)
Pages (from-to)348-355
Number of pages8
JournalMagnetic resonance in medicine
Volume66
Issue number2
DOIs
StatePublished - Aug 2011

Keywords

  • MRI
  • dGEMRIC
  • femoroacetabular impingement
  • hip, cartilage
  • radial MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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