A call to arms: coevolution of animal viruses and host innate immune responses

Joao T. Marques*, Richard W Carthew

*Corresponding author for this work

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

Virus infection is generally disadvantageous to the host and strongly selects for host antiviral mechanisms. Therefore, viruses must develop counter-mechanisms to guarantee their survival. This arms race between pathogen and host leads to positive selection for both cellular antiviral mechanisms and viral inhibitors of such mechanisms. Here, we characterize this arms race in the context of the RNA interference (RNAi) pathway, which is used as an innate immune response against viral infection by animals. We review how RNAi is used as an antiviral strategy and the mechanisms that viruses have evolved to suppress the RNAi response.

Original languageEnglish (US)
Pages (from-to)359-364
Number of pages6
JournalTrends in Genetics
Volume23
Issue number7
DOIs
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Genetics

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