A call to arms: coevolution of animal viruses and host innate immune responses

Joao T. Marques; Richard W. Carthew

doi:10.1016/j.tig.2007.04.004

A call to arms: coevolution of animal viruses and host innate immune responses

Joao T. Marques^*, Richard W. Carthew

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Virus infection is generally disadvantageous to the host and strongly selects for host antiviral mechanisms. Therefore, viruses must develop counter-mechanisms to guarantee their survival. This arms race between pathogen and host leads to positive selection for both cellular antiviral mechanisms and viral inhibitors of such mechanisms. Here, we characterize this arms race in the context of the RNA interference (RNAi) pathway, which is used as an innate immune response against viral infection by animals. We review how RNAi is used as an antiviral strategy and the mechanisms that viruses have evolved to suppress the RNAi response.

Original language	English (US)
Pages (from-to)	359-364
Number of pages	6
Journal	Trends in Genetics
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.tig.2007.04.004
State	Published - Jul 2007

Funding

We thank Susan Besson for helpful comments on the manuscript. This work was funded by the NIH (GM68743 and GM72830).

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/j.tig.2007.04.004

Cite this

@article{ca6bbcaab52440bd917c2504ceffba57,

title = "A call to arms: coevolution of animal viruses and host innate immune responses",

abstract = "Virus infection is generally disadvantageous to the host and strongly selects for host antiviral mechanisms. Therefore, viruses must develop counter-mechanisms to guarantee their survival. This arms race between pathogen and host leads to positive selection for both cellular antiviral mechanisms and viral inhibitors of such mechanisms. Here, we characterize this arms race in the context of the RNA interference (RNAi) pathway, which is used as an innate immune response against viral infection by animals. We review how RNAi is used as an antiviral strategy and the mechanisms that viruses have evolved to suppress the RNAi response.",

author = "Marques, {Joao T.} and Carthew, {Richard W.}",

note = "Funding Information: We thank Susan Besson for helpful comments on the manuscript. This work was funded by the NIH (GM68743 and GM72830).",

year = "2007",

month = jul,

doi = "10.1016/j.tig.2007.04.004",

language = "English (US)",

volume = "23",

pages = "359--364",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Ltd",

number = "7",

}

TY - JOUR

T1 - A call to arms

T2 - coevolution of animal viruses and host innate immune responses

AU - Marques, Joao T.

AU - Carthew, Richard W.

N1 - Funding Information: We thank Susan Besson for helpful comments on the manuscript. This work was funded by the NIH (GM68743 and GM72830).

PY - 2007/7

Y1 - 2007/7

N2 - Virus infection is generally disadvantageous to the host and strongly selects for host antiviral mechanisms. Therefore, viruses must develop counter-mechanisms to guarantee their survival. This arms race between pathogen and host leads to positive selection for both cellular antiviral mechanisms and viral inhibitors of such mechanisms. Here, we characterize this arms race in the context of the RNA interference (RNAi) pathway, which is used as an innate immune response against viral infection by animals. We review how RNAi is used as an antiviral strategy and the mechanisms that viruses have evolved to suppress the RNAi response.

AB - Virus infection is generally disadvantageous to the host and strongly selects for host antiviral mechanisms. Therefore, viruses must develop counter-mechanisms to guarantee their survival. This arms race between pathogen and host leads to positive selection for both cellular antiviral mechanisms and viral inhibitors of such mechanisms. Here, we characterize this arms race in the context of the RNA interference (RNAi) pathway, which is used as an innate immune response against viral infection by animals. We review how RNAi is used as an antiviral strategy and the mechanisms that viruses have evolved to suppress the RNAi response.

UR - http://www.scopus.com/inward/record.url?scp=34250738281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250738281&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2007.04.004

DO - 10.1016/j.tig.2007.04.004

M3 - Review article

C2 - 17467114

AN - SCOPUS:34250738281

SN - 0168-9525

VL - 23

SP - 359

EP - 364

JO - Trends in Genetics

JF - Trends in Genetics

IS - 7

ER -

A call to arms: coevolution of animal viruses and host innate immune responses

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this