A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

Jennifer Strong; Albert E. Zhou; Fahad Alkaabba; Danielle Soldin; Joanne Moon; Hanan Alharthy; Owais Syed; Yuchen Liu; Kathryn Turney; Janina Markidan; Laura Malone; Seung Tae Lee; Peter Derosa

doi:10.1159/000527597

A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

Jennifer Strong, Albert E. Zhou, Fahad Alkaabba, Danielle Soldin, Joanne Moon, Hanan Alharthy, Owais Syed, Yuchen Liu, Kathryn Turney, Janina Markidan, Laura Malone, Seung Tae Lee, Peter Derosa^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare painful skin condition that is characterized by hyperpyrexia, peripheral blood and skin neutrophilia, and edematous skin lesions. Necrotizing SS (NSS) is a severe and locally aggressive condition that histopathologically resembles a necrotizing soft tissue infection. As opposed to necrotizing soft tissue infections, NSS responds to systemic steroids. SS is divided into three subtypes: classical SS, malignancy-associated SS, and drug-induced SS. Within the malignancy-associated SS subtype, both solid tumor and hematologic malignancies have been precursors to developing SS. Here, we present a case of acute myeloid leukemia-associated NSS.

Original language	English (US)
Pages (from-to)	339-343
Number of pages	5
Journal	Case Reports in Dermatology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1159/000527597
State	Published - Nov 7 2022

Keywords

Hematology
Leukemia
Necrotizing fasciitis
Oncology
Sweet syndrome

ASJC Scopus subject areas

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000527597

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title = "A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome",

abstract = "Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare painful skin condition that is characterized by hyperpyrexia, peripheral blood and skin neutrophilia, and edematous skin lesions. Necrotizing SS (NSS) is a severe and locally aggressive condition that histopathologically resembles a necrotizing soft tissue infection. As opposed to necrotizing soft tissue infections, NSS responds to systemic steroids. SS is divided into three subtypes: classical SS, malignancy-associated SS, and drug-induced SS. Within the malignancy-associated SS subtype, both solid tumor and hematologic malignancies have been precursors to developing SS. Here, we present a case of acute myeloid leukemia-associated NSS.",

keywords = "Hematology, Leukemia, Necrotizing fasciitis, Oncology, Sweet syndrome",

author = "Jennifer Strong and Zhou, {Albert E.} and Fahad Alkaabba and Danielle Soldin and Joanne Moon and Hanan Alharthy and Owais Syed and Yuchen Liu and Kathryn Turney and Janina Markidan and Laura Malone and Lee, {Seung Tae} and Peter Derosa",

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doi = "10.1159/000527597",

language = "English (US)",

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journal = "Case Reports in Dermatology",

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T1 - A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

AU - Strong, Jennifer

AU - Zhou, Albert E.

AU - Alkaabba, Fahad

AU - Soldin, Danielle

AU - Moon, Joanne

AU - Alharthy, Hanan

AU - Syed, Owais

AU - Liu, Yuchen

AU - Turney, Kathryn

AU - Markidan, Janina

AU - Malone, Laura

AU - Lee, Seung Tae

AU - Derosa, Peter

PY - 2022/11/7

Y1 - 2022/11/7

N2 - Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare painful skin condition that is characterized by hyperpyrexia, peripheral blood and skin neutrophilia, and edematous skin lesions. Necrotizing SS (NSS) is a severe and locally aggressive condition that histopathologically resembles a necrotizing soft tissue infection. As opposed to necrotizing soft tissue infections, NSS responds to systemic steroids. SS is divided into three subtypes: classical SS, malignancy-associated SS, and drug-induced SS. Within the malignancy-associated SS subtype, both solid tumor and hematologic malignancies have been precursors to developing SS. Here, we present a case of acute myeloid leukemia-associated NSS.

AB - Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare painful skin condition that is characterized by hyperpyrexia, peripheral blood and skin neutrophilia, and edematous skin lesions. Necrotizing SS (NSS) is a severe and locally aggressive condition that histopathologically resembles a necrotizing soft tissue infection. As opposed to necrotizing soft tissue infections, NSS responds to systemic steroids. SS is divided into three subtypes: classical SS, malignancy-associated SS, and drug-induced SS. Within the malignancy-associated SS subtype, both solid tumor and hematologic malignancies have been precursors to developing SS. Here, we present a case of acute myeloid leukemia-associated NSS.

KW - Hematology

KW - Leukemia

KW - Necrotizing fasciitis

KW - Oncology

KW - Sweet syndrome

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U2 - 10.1159/000527597

DO - 10.1159/000527597

M3 - Article

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SN - 1662-6567

VL - 14

SP - 339

EP - 343

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 3

ER -

A Case of Acute Myeloid Leukemia-Associated Necrotizing Sweet Syndrome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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