A case of atypical hemolytic uremic syndrome in a second renal transplant

Nicholas A. Zwang*, Bing Ho, Yashpal S. Kanwar, Brad Lewis, Matthew Cusick, John J. Friedewald, Lorenzo Gallon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Atypical hemolytic uremic syndrome (aHUS) has gained increased visibility over several years as an important cause of renal failure. Unfortunately, diagnosis is often difficult because individual courses can be highly variable depending the causative genetic mutations. Here we present the case of a patient with a failed renal allograft and acute failure of a second allograft who was ultimately diagnosed with aHUS. Interestingly, he developed early de novo donor specific antibodies (DSA) after the second renal transplant in context of likely recurrent aHUS. Terminal complement inhibition with eculizumab resulted in prompt improvement of renal allograft function.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalJournal of Nephrology
Issue number1
StatePublished - Feb 1 2018


  • Atypical hemolytic uremic syndrome
  • Complement biology
  • Graft failure
  • Histocompatibility
  • Kidney transplantation

ASJC Scopus subject areas

  • Nephrology


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