A case of Good's syndrome complicated by erythema multiforme

Laura R. Glick, William Wyatt Wilson, Michelle Fletcher*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Good's syndrome (GS) is a rare, adult-onset combined B cell and T cell immunodeficiency with an associated thymoma. These patients have an increased risk of bacterial, fungal, viral and opportunistic infections. This report describes a 75-year-old female patient who presented with a full body rash and an anterior mediastinal mass. She underwent a biopsy of her rash and mass, which revealed erythema multiforme and WHO Type A thymoma, respectively. During her hospitalisation, she was also found to have oropharyngeal candidiasis, methicillin-susceptible Staphylococcus aureus bacteraemia and herpes simplex virus type 2 (HSV-2) skin lesions. Based on the number of infections and severity of her rash, an immunocompromised state was suspected. Immunological testing revealed a B cell and T cell deficiency as well as low serum immunoglobulins. This combination of hypogammaglobulinaemia and thymoma led to a diagnosis of GS. While there have been many case reports of GS, this is the first report of the immunodeficiency presenting with erythema multiforme.

Original languageEnglish (US)
Article numbere229999
JournalBMJ case reports
Issue number8
StatePublished - 2019


  • dermatology
  • immunology
  • infectious diseases
  • respiratory medicine

ASJC Scopus subject areas

  • Medicine(all)


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