Serotonin syndrome is usually seen in patients who are on serotonergic agents such as an SSRI and MAO inhibitor. Medications that affect serotonin metabolism and induce the syndrome include MAOIs, antidepressants, opioids, cough medicines, and illicit drugs. The mechanisms in its development include inhibition of reuptake of serotonin, enhanced presynaptic release, and MAO inhibition. The clinical triad includes mental status changes, autonomic hyperactivity, and neuromuscular abnormalities (myoclonus, hyperreflexia, rigidity). Diagnostic criteria include the Sternbach and the Hunter criteria. Treatments include supportive therapy and cyproheptadine, a benzodiazepine and 5-HT2A antagonist.
|Original language||English (US)|
|Title of host publication||Challenging Cases and Complication Management in Pain Medicine|
|Publisher||Springer International Publishing|
|Number of pages||4|
|Publication status||Published - Jan 1 2017|
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