A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation

Xunrong Luo*, Yayoi Ikeda, Keith L. Parker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1278 Scopus citations

Abstract

Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues.

Original languageEnglish (US)
Pages (from-to)481-490
Number of pages10
JournalCell
Volume77
Issue number4
DOIs
StatePublished - May 20 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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