A central role for inducible heat-shock protein 70 in autoimmune vitiligo

Jeffrey A. Mosenson, Jonathan M. Eby, Claudia Hernandez, I. Caroline Le Poole*

*Corresponding author for this work

Research output: Contribution to journalLetter

30 Citations (Scopus)

Abstract

Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen-bound HSP70i to act as an alarm signal in activating DCs that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo.

Original languageEnglish (US)
Pages (from-to)566-569
Number of pages4
JournalExperimental Dermatology
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2013

Fingerprint

Vitiligo
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Dendritic Cells
Autoimmunity
Melanocytes
Immunity
Proteins
Apoptosis
Antigens
Infection

Keywords

  • Autoimmune
  • Dendritic cell
  • Depigmentation
  • Heat-shock protein
  • Mouse model
  • Stress
  • T cell

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Mosenson, Jeffrey A. ; Eby, Jonathan M. ; Hernandez, Claudia ; Le Poole, I. Caroline. / A central role for inducible heat-shock protein 70 in autoimmune vitiligo. In: Experimental Dermatology. 2013 ; Vol. 22, No. 9. pp. 566-569.
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A central role for inducible heat-shock protein 70 in autoimmune vitiligo. / Mosenson, Jeffrey A.; Eby, Jonathan M.; Hernandez, Claudia; Le Poole, I. Caroline.

In: Experimental Dermatology, Vol. 22, No. 9, 01.09.2013, p. 566-569.

Research output: Contribution to journalLetter

TY - JOUR

T1 - A central role for inducible heat-shock protein 70 in autoimmune vitiligo

AU - Mosenson, Jeffrey A.

AU - Eby, Jonathan M.

AU - Hernandez, Claudia

AU - Le Poole, I. Caroline

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AB - Inducible heat-shock protein 70 (HSP70i) is a protein regulated by stress that protects cells from undergoing apoptosis. Such proteins are marvellously well conserved throughout evolution, which has placed them in the spotlight for helping to understand the intriguing relationship between infection and immunity. In the presence of stress proteins, dendritic cells (DCs) will sense this alarm signal and respond by recruiting immune cells of different plumage to fit the occasion. In times of stress, melanocytes will secrete antigen-bound HSP70i to act as an alarm signal in activating DCs that comes equipped with an address of origin to drive the autoimmune response in vitiligo. Here we pose that if the autoimmune response is funnelled through HSP70i, then blocking the stress protein from activating DCs can lend new treatment opportunities for vitiligo.

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KW - Dendritic cell

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