A child with both Langerhans and non-Langerhans cell histiocytosis

Ayelet Shani-Adir, Pauline M Chou, Elaine R Morgan, Anthony J Mancini*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The histiocytic syndromes consist of a group of disorders that share in common the proliferation of cells of the monocytic/macrophage lineage. It has been conventional to divide the histiocytoses into two separate groups: Langerhans cell histiocytosis (LCH) and non-LCH. We present a 2-year-old Hispanic boy who was referred to the dermatology clinic for evaluation of an asymptomatic cutaneous eruption of the head and upper trunk. In addition, he had a 3-week history of pain in his right leg and difficulty in walking. The patient's physical examination was normal, excluding the skin findings. On plain radiography, multiple lytic lesions in the skull, lumbar spine, and right tibia were seen. Histopathologic examination of a skin biopsy specimen revealed a predominantly histiocytic infiltrate in the dermis which was negative for S-100 and CD1a stains. A tibial biopsy specimen showed a monomorphous infiltrate of histiocytes that were S-100 and CD1a positive. This patient's concomitant findings of both LCH and non-LCH histiocytoses further support a potential overlap within the histiocytic syndromes, as has been suggested by others.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalPediatric dermatology
Volume19
Issue number5
DOIs
StatePublished - Sep 1 2002

Fingerprint

Non-Langerhans-Cell Histiocytosis
Histiocytosis
Langerhans Cell Histiocytosis
Skin
Mobility Limitation
Biopsy
Histiocytes
Dermis
Dermatology
Tibia
Hispanic Americans
Skull
Radiography
Physical Examination
Leg
Spine
Coloring Agents
Macrophages
Head
Cell Proliferation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

Cite this

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title = "A child with both Langerhans and non-Langerhans cell histiocytosis",
abstract = "The histiocytic syndromes consist of a group of disorders that share in common the proliferation of cells of the monocytic/macrophage lineage. It has been conventional to divide the histiocytoses into two separate groups: Langerhans cell histiocytosis (LCH) and non-LCH. We present a 2-year-old Hispanic boy who was referred to the dermatology clinic for evaluation of an asymptomatic cutaneous eruption of the head and upper trunk. In addition, he had a 3-week history of pain in his right leg and difficulty in walking. The patient's physical examination was normal, excluding the skin findings. On plain radiography, multiple lytic lesions in the skull, lumbar spine, and right tibia were seen. Histopathologic examination of a skin biopsy specimen revealed a predominantly histiocytic infiltrate in the dermis which was negative for S-100 and CD1a stains. A tibial biopsy specimen showed a monomorphous infiltrate of histiocytes that were S-100 and CD1a positive. This patient's concomitant findings of both LCH and non-LCH histiocytoses further support a potential overlap within the histiocytic syndromes, as has been suggested by others.",
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A child with both Langerhans and non-Langerhans cell histiocytosis. / Shani-Adir, Ayelet; Chou, Pauline M; Morgan, Elaine R; Mancini, Anthony J.

In: Pediatric dermatology, Vol. 19, No. 5, 01.09.2002, p. 419-422.

Research output: Contribution to journalArticle

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