A Circuit Encoding Absolute Cold Temperature in Drosophila

Michael H. Alpert, Dominic D. Frank, Evan Kaspi, Matthieu Flourakis, Emanuela E. Zaharieva, Ravi Allada, Alessia Para, Marco Gallio*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Animals react to environmental changes over timescales ranging from seconds to days and weeks. An important question is how sensory stimuli are parsed into neural signals operating over such diverse temporal scales. Here, we uncover a specialized circuit, from sensory neurons to higher brain centers, that processes information about long-lasting, absolute cold temperature in Drosophila. We identify second-order thermosensory projection neurons (TPN-IIs) exhibiting sustained firing that scales with absolute temperature. Strikingly, this activity only appears below the species-specific, preferred temperature for D. melanogaster (∼25°C). We trace the inputs and outputs of TPN-IIs and find that they are embedded in a cold “thermometer” circuit that provides powerful and persistent inhibition to brain centers involved in regulating sleep and activity. Our results demonstrate that the fly nervous system selectively encodes and relays absolute temperature information and illustrate a sensory mechanism that allows animals to adapt behavior specifically to cold conditions on the timescale of hours to days. Alpert et al. uncover a specialized circuit, from sensory neurons to higher brain centers that processes information about absolute cold temperature in Drosophila. This circuit directly connects thermosensory neurons of the antenna with circadian and sleep centers in the brain, adapting sleep and activity specifically to cold conditions.

Original languageEnglish (US)
JournalCurrent Biology
DOIs
StateAccepted/In press - 2020

Keywords

  • Drosophila
  • antenna
  • brain
  • circuit
  • cold
  • seasonal
  • sleep
  • temperature
  • thermosensory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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