A clinically applicable approach for detecting spontaneous action potential spikes in amyotrophic lateral sclerosis with a linear electrode array

Faezeh Jahanmiri-Nezhad, Xiaoyan Li, Paul E. Barkhaus, William Z. Rymer, Ping Zhou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Examination of spontaneous muscle activity is an important part of the routine electromyogram (EMG) in assessing neuromuscular diseases. The EMG is specifically valuable as a diagnostic test in supporting the diagnosis of amyotrophic lateral sclerosis. High-density surface EMG is a relatively new technique that has until now been used in research but has the potential for clinical application. This study presents a simple high-density surface EMG method for automatic detection of spontaneous action potentials from surface electrode array recordings of patients with amyotrophic lateral sclerosis. To reduce computational complexity while maintaining useful information from the electrode array recording, the multichannel high-density surface EMG was transferred to single-dimensional data by calculating the maximum difference across all channels of the electrode array. A spike detection threshold was then set in the single-dimensional domain to identify the firing times of each spontaneous action potential spike, whereas a spike extraction threshold was used to define the onset and offset of the spontaneous spikes. These data were used to extract the spontaneous spike waveforms from the electrode array EMG. A database of detected spontaneous spikes was thus obtained, including their waveforms, on all channels along with their corresponding firing times. This newly developed method makes use of the information from different channels of the electrode array EMG recording. It also has the primary feature of being simple and fast in implementation, with convenient parameter adjustment and user-computer interaction. Hence, it has good possibilities for clinical application.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalJournal of Clinical Neurophysiology
Volume31
Issue number1
DOIs
StatePublished - Feb 2014

Keywords

  • ALS
  • EMG
  • electrode array
  • spike detection

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'A clinically applicable approach for detecting spontaneous action potential spikes in amyotrophic lateral sclerosis with a linear electrode array'. Together they form a unique fingerprint.

Cite this