A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Haijun Chen; Cheng Z. Wang; Chunyong Ding; Christopher Wild; Bryan Copits; Geoffrey T. Swanson; Kenneth M. Johnson; Jia Zhou

doi:10.1002/cmdc.201200554

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Haijun Chen, Cheng Z. Wang, Chunyong Ding, Christopher Wild, Bryan Copits, Geoffrey T. Swanson, Kenneth M. Johnson, Jia Zhou^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency invitro and efficacy invivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.

Original language	English (US)
Pages (from-to)	226-230
Number of pages	5
Journal	ChemMedChem
Volume	8
Issue number	2
DOIs	https://doi.org/10.1002/cmdc.201200554
State	Published - Feb 2013

Funding

Keywords

Bioinformatics
Biological space
Chemical space
Chemoinformatics
Drug design
Neuroprotective agents

ASJC Scopus subject areas

Drug Discovery
General Pharmacology, Toxicology and Pharmaceutics
Molecular Medicine
Biochemistry
Pharmacology
Organic Chemistry

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title = "A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents",

abstract = "PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency invitro and efficacy invivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.",

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AU - Chen, Haijun

AU - Wang, Cheng Z.

AU - Ding, Chunyong

AU - Wild, Christopher

AU - Copits, Bryan

AU - Swanson, Geoffrey T.

AU - Johnson, Kenneth M.

AU - Zhou, Jia

PY - 2013/2

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AB - PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency invitro and efficacy invivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.

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KW - Biological space

KW - Chemical space

KW - Chemoinformatics

KW - Drug design

KW - Neuroprotective agents

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A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Abstract

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Keywords

ASJC Scopus subject areas

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