A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Haixia Yang, Weicang Wang, Kymberleigh A. Romano, Min Gu, Katherine Z. Sanidad, Daeyoung Kim, Jun Yang, Birgitta Schmidt, Dipak Panigrahy, Ruisong Pei, Derek A. Martin, E. Ilker Ozay, Yuxin Wang, Mingyue Song, Bradley W. Bolling, Hang Xiao, Lisa M. Minter, Guang Yu Yang, Zhenhua Liu, Federico E. ReyGuodong Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. In addition, TCS treatment increases activation of Toll-like receptor 4 (TLR4) signaling in vivo and fails to promote colitis in Tlr4-/-mice. Together, our results demonstrate that this widely used antimicrobial ingredient could have adverse effects on colonic inflammation and associated colon tumorigenesis through modulation of the gut microbiota and TLR4 signaling. Together, these results highlight the need to reassess the effects of TCS on human health and potentially update policies regulating the use of this widely used antimicrobial.

Original languageEnglish (US)
Article numbereaan4116
JournalScience translational medicine
Volume10
Issue number443
DOIs
StatePublished - May 30 2018

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice'. Together they form a unique fingerprint.

  • Cite this

    Yang, H., Wang, W., Romano, K. A., Gu, M., Sanidad, K. Z., Kim, D., Yang, J., Schmidt, B., Panigrahy, D., Pei, R., Martin, D. A., Ilker Ozay, E., Wang, Y., Song, M., Bolling, B. W., Xiao, H., Minter, L. M., Yang, G. Y., Liu, Z., ... Zhang, G. (2018). A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Science translational medicine, 10(443), [eaan4116]. https://doi.org/10.1126/scitranslmed.aan4116