A common variant associated with prostate cancer in European and African populations

Laufey T. Amundadottir, Patrick Sulem, Julius Gudmundsson, Agnar Helgason, Adam Baker, Bjarni A. Agnarsson, Asgeir Sigurdsson, Kristrun R. Benediktsdottir, Jean Baptiste Cazier, Jesus Sainz, Margret Jakobsdottir, Jelena Kostic, Droplaug N. Magnusdottir, Shyamali Ghosh, Kari Agnarsson, Birgitta Birgisdottir, Louise Le Roux, Adalheidur Olafsdottir, Thorarinn Blondal, Margret AndresdottirOlafia Svandis Gretarsdottir, Jon T. Bergthorsson, Daniel Gudbjartsson, Arnaldur Gylfason, Gudmar Thorleifsson, Andrei Manolescu, Kristleifur Kristjansson, Gudmundur Geirsson, Helgi Isaksson, Julie Douglas, Jan Erik Johansson, Katarina Bälter, Fredrik Wiklund, James E. Montie, Xiaoying Yu, Brian K. Suarez, Carole Ober, Kathleen A. Cooney, Henrik Gronberg, William J. Catalona, Gudmundur V. Einarsson, Rosa B. Barkardottir, Jeffrey R. Gulcher, Augustine Kong, Unnur Thorsteinsdottir*, Kari Stefansson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

577 Scopus citations

Abstract

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P ≤ 2.7 × 10-11). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of ∼8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

Original languageEnglish (US)
Pages (from-to)652-658
Number of pages7
JournalNature Genetics
Volume38
Issue number6
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Genetics

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