TY - JOUR
T1 - A community-based study of tobacco smoke exposure among inner-city children with asthma in Chicago
AU - Kumar, Rajesh
AU - Curtis, Laura Marie
AU - Khiani, Sanjay
AU - Moy, James
AU - Shalowitz, Madeleine U.
AU - Sharp, Lisa
AU - Durazo-Arvizu, Ramon A.
AU - Shannon, John Jay
AU - Weiss, Kevin B.
N1 - Funding Information:
Disclosure of potential conflict of interest: R. Kumar has received research support from Versu Pharmaceuticals. L. M. Curtis has received research support from the National Institutes of Health. J. Moy has received research support from Merck. M. U. Shalowitz has received research support from the National Institute of Child Health and Development and the National Heart, Lung, and Blood Institute (NHLBI). J. J. Shannon has received research support from the NHLBI.
Funding Information:
Supported by National Heart, Lung, and Blood Institute grant 1UO1 HL072496-01.
PY - 2008/10
Y1 - 2008/10
N2 - Background: Little is known about the level of tobacco exposure and the factors that influence exposure in children with persistent asthma. Objective: We sought to measure tobacco smoke exposure and determine factors associated with exposure in a large urban sample of asthmatic children. Methods: This cross-sectional study is based on a community-based cohort of 482 children (8-14 years old) with persistent asthma. Caregiver and household tobacco use were reported by the caregiver. Child tobacco smoke exposure was assessed by using salivary cotinine level. Multivariate linear regression of log-transformed salivary cotinine levels were used to characterize the relationship between smoke exposure and caregiver, household, and demographic characteristics. We used a multivariate logistic model to characterize associations with caregiver smoking. Results: Overall, 68.5% of children had tobacco smoke exposure. Compared with nonexposed children, those exposed to smoking by a caregiver or another household member had cotinine levels that were 1.68 (95% CI, 1.45-1.94) or 1.40 (95% CI, 1.22-1.62) times higher, respectively. Compared with Hispanic children, African American and white/other children had 1.55 (95% CI, 1.16-2.06) and 1.59 (95% CI, 1.18-2.14) times higher cotinine levels, respectively. Child exposure was also associated with caregiver depression symptoms (odds ratio, 1.01; 95% CI, 1.01-1.02), and higher household income was protective (odds ratio, 0.73; 95% CI, 0.56-0.95). Independent predictors of caregiver smoking included a protective effect of higher education (odds ratio, 0.35; 95% CI, 0.15-0.83) and a positive association with potential problematic drug/alcohol use (odds ratio, 2.30; 95% CI, 1.39-3.83). Conclusions: Tobacco smoke exposure was high in this urban sample of asthmatic children. Caregiver smoking was strongly associated with child exposure and also was associated with lower socioeconomic status, non-Hispanic ethnicity, and depression symptoms.
AB - Background: Little is known about the level of tobacco exposure and the factors that influence exposure in children with persistent asthma. Objective: We sought to measure tobacco smoke exposure and determine factors associated with exposure in a large urban sample of asthmatic children. Methods: This cross-sectional study is based on a community-based cohort of 482 children (8-14 years old) with persistent asthma. Caregiver and household tobacco use were reported by the caregiver. Child tobacco smoke exposure was assessed by using salivary cotinine level. Multivariate linear regression of log-transformed salivary cotinine levels were used to characterize the relationship between smoke exposure and caregiver, household, and demographic characteristics. We used a multivariate logistic model to characterize associations with caregiver smoking. Results: Overall, 68.5% of children had tobacco smoke exposure. Compared with nonexposed children, those exposed to smoking by a caregiver or another household member had cotinine levels that were 1.68 (95% CI, 1.45-1.94) or 1.40 (95% CI, 1.22-1.62) times higher, respectively. Compared with Hispanic children, African American and white/other children had 1.55 (95% CI, 1.16-2.06) and 1.59 (95% CI, 1.18-2.14) times higher cotinine levels, respectively. Child exposure was also associated with caregiver depression symptoms (odds ratio, 1.01; 95% CI, 1.01-1.02), and higher household income was protective (odds ratio, 0.73; 95% CI, 0.56-0.95). Independent predictors of caregiver smoking included a protective effect of higher education (odds ratio, 0.35; 95% CI, 0.15-0.83) and a positive association with potential problematic drug/alcohol use (odds ratio, 2.30; 95% CI, 1.39-3.83). Conclusions: Tobacco smoke exposure was high in this urban sample of asthmatic children. Caregiver smoking was strongly associated with child exposure and also was associated with lower socioeconomic status, non-Hispanic ethnicity, and depression symptoms.
KW - Inner-city asthma
KW - child
KW - cotinine
KW - tobacco smoke exposure
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U2 - 10.1016/j.jaci.2008.08.006
DO - 10.1016/j.jaci.2008.08.006
M3 - Article
C2 - 19014767
AN - SCOPUS:53049099439
VL - 122
SP - 754-759.e1
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 4
ER -
