A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus

Yueqin Zhou, Xiaotong Yang*, Xuquan Li, Huiqin Feng, Ke Mi, Qingyao Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalFrontiers of Biology in China
Volume1
Issue number3
DOIs
StatePublished - Sep 2006
Externally publishedYes

Funding

Acknowledgements This paper was supported by the Shanghai

Keywords

  • Anti-proliferation
  • Apoptosis
  • Ganoderma
  • HL-60

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics

Fingerprint

Dive into the research topics of 'A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus'. Together they form a unique fingerprint.

Cite this