A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus

Yueqin Zhou; Xiaotong Yang; Xuquan Li; Huiqin Feng; Ke Mi; Qingyao Yang

doi:10.1007/s11515-006-0034-7

A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus

Yueqin Zhou, Xiaotong Yang^*, Xuquan Li, Huiqin Feng, Ke Mi, Qingyao Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.

Original language	English (US)
Pages (from-to)	275-279
Number of pages	5
Journal	Frontiers of Biology in China
Volume	1
Issue number	3
DOIs	https://doi.org/10.1007/s11515-006-0034-7
State	Published - Sep 2006
Externally published	Yes

Funding

Acknowledgements This paper was supported by the Shanghai

Keywords

Anti-proliferation
Apoptosis
Ganoderma
HL-60

ASJC Scopus subject areas

Biotechnology
Ecology, Evolution, Behavior and Systematics
Ecology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11515-006-0034-7

Cite this

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title = "A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus",

abstract = "Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.",

keywords = "Anti-proliferation, Apoptosis, Ganoderma, HL-60",

author = "Yueqin Zhou and Xiaotong Yang and Xuquan Li and Huiqin Feng and Ke Mi and Qingyao Yang",

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doi = "10.1007/s11515-006-0034-7",

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AU - Zhou, Yueqin

AU - Yang, Xiaotong

AU - Li, Xuquan

AU - Feng, Huiqin

AU - Mi, Ke

AU - Yang, Qingyao

N1 - Funding Information: Acknowledgements This paper was supported by the Shanghai

PY - 2006/9

Y1 - 2006/9

N2 - Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.

AB - Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.

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KW - Apoptosis

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A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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