Abstract
Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.
Original language | English (US) |
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Pages (from-to) | 275-279 |
Number of pages | 5 |
Journal | Frontiers of Biology in China |
Volume | 1 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2006 |
Externally published | Yes |
Funding
Acknowledgements This paper was supported by the Shanghai
Keywords
- Anti-proliferation
- Apoptosis
- Ganoderma
- HL-60
ASJC Scopus subject areas
- Biotechnology
- Ecology, Evolution, Behavior and Systematics
- Ecology
- Genetics