A comparison of iohexol and diatrizoate–meglumine in children undergoing cardiac catheterization

Andrew N. Pelech*, Shelley M. Allard, Richard T. Hurd, Niels G. Giddins, George F. Collins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Iohexol (Omnipaque) and meglumine and sodium diatrizoate (Renografin-76) were compared in a double-blind, randomized study for their efficacy, safety, and hemodynamic effects as angiographic contrast agents in children. Forty-four children were randomly allocated to receive either iohexol or diatrizoate as a component of their routine or emergency cardiovascular evaluation. Following age stratification, baseline physiologic parameters were not significantly different between patients receiving either iohexol or diatrizoate. After systemic ventricular injection, iohexol produced significantly less hemodynamic alteration in systemic systolic blood pressure, systemic ventricular end-diastolic pressure, and dP/dt. Less alteration in heart rate and significantly less effect on the QT interval were seen with iohexol. Image quality was comparable, although significantly more patient mobility was associated with diatrizoate-meglumine. This study shows that iohexol, a nonionic contrast medium, causes less hemodynamic disturbance than diatrizoate-meglumine in children. Therefore, its use is to be preferred in these potentially high-risk patients.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalInvestigative radiology
Issue number7
StatePublished - Jul 1991
Externally publishedYes


  • Angiocardiography
  • Contrast media
  • Diatrizoate-meglumine
  • Iohexol

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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